Department of Global Health and Population, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, Massachusetts, United States of America (USA).
MRC/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Bull World Health Organ. 2019 Jan 1;97(1):10-23. doi: 10.2471/BLT.18.217000. Epub 2018 Oct 31.
To examine how multimorbidity might affect progression along the continuum of care among older adults with hypertension, diabetes and human immunodeficiency virus (HIV) infection in rural South Africa.
We analysed data from 4447 people aged 40 years or older who were enrolled in a longitudinal study in Agincourt sub-district. Household-based interviews were completed between November 2014 and November 2015. For hypertension and diabetes (2813 and 512 people, respectively), we defined concordant conditions as other cardiometabolic conditions, and discordant conditions as mental disorders or HIV infection. For HIV infection (1027 people) we defined any other conditions as discordant. Regression models were fitted to assess the relationship between the type of multimorbidity and progression along the care continuum and the likelihood of patients being in each stage of care for the index condition (four stages from testing to treatment).
People with hypertension or diabetes plus other cardiometabolic conditions were more like to progress through the care continuum for the index condition than those without cardiometabolic conditions (relative risk, RR: 1.14, 95% confidence interval, CI: 1.09-1.20, and RR: 2.18, 95% CI: 1.52-3.26, respectively). Having discordant comorbidity was associated with greater progression in care for those with hypertension but not diabetes. Those with HIV infection plus cardiometabolic conditions had less progress in the stages of care compared with those without such conditions (RR: 0.86, 95% CI: 0.80-0.92).
Patients with concordant conditions were more likely to progress further along the care continuum, while those with discordant multimorbidity tended not to progress beyond diagnosis.
探讨在南非农村,多重合并症如何影响患有高血压、糖尿病和人类免疫缺陷病毒(HIV)感染的老年人沿着医疗保健连续统的进展。
我们分析了在阿格因库尔特区进行的一项纵向研究中 4447 名 40 岁或以上人群的数据。家庭访谈于 2014 年 11 月至 2015 年 11 月进行。对于高血压和糖尿病(分别为 2813 人和 512 人),我们将一致的合并症定义为其他心血管代谢疾病,而不一致的合并症定义为精神障碍或 HIV 感染。对于 HIV 感染(1027 人),我们将任何其他条件定义为不一致。回归模型用于评估不同类型的多重合并症与沿着医疗保健连续统的进展以及患者在指数疾病的每个治疗阶段的可能性之间的关系(从检测到治疗的四个阶段)。
患有高血压或糖尿病加其他心血管代谢疾病的患者比没有心血管代谢疾病的患者更有可能沿着指数疾病的医疗保健连续统进展(相对风险,RR:1.14,95%置信区间,CI:1.09-1.20,和 RR:2.18,95% CI:1.52-3.26)。不一致的合并症与高血压患者的护理进展相关,但与糖尿病患者无关。患有 HIV 感染加心血管代谢疾病的患者在护理阶段的进展比没有这种疾病的患者要少(RR:0.86,95% CI:0.80-0.92)。
患有一致合并症的患者更有可能沿着医疗保健连续统进一步进展,而患有不一致的多重合并症的患者往往不会超出诊断阶段。