Wang Feng-Li, Wang Yue-Hua, Han Lin, An Hai-Yan, Zhang Jiang-Hua, Zhang Xue-Yun, Chen Zhi-Qiang, Qin Jian-Guo
Central Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Department of Nephropathy, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050081, China.
Evid Based Complement Alternat Med. 2018 Dec 6;2018:4276052. doi: 10.1155/2018/4276052. eCollection 2018.
Diabetic nephropathy is developed in 20-40% of patients with diabetes mellitus, and patients with diabetic nephropathy require dialysis and renal transplantation. Traditional Chinese medicine has been widely used in treating patients with diabetic nephropathy in China. However, the detailed mechanisms of traditional Chinese medicine remain unclear. Yiqi Yangyin Huayu Tongluo formula (ZY formula) is a traditional Chinese medicinal formula. Here, we demonstrated kidney protective effect of ZY formula on the rats with diabetic nephropathy. The therapeutic effect of ZY formula on the diabetic nephropathy was almost the same as that of Irbesartan, which proved to have excellent curative effects on diabetic nephropathy. We also demonstrated the mechanism of ZY formula effect on the diabetic nephropathy. First, we validated that the activation of ROS-JNK signaling pathway in diabetic rats could be reduced by ZY. Furthermore, collagen I expression could be downregulated by ZY formula treatment. Meanwhile, cell apoptosis in the kidney of diabetic rats could be alleviated by ZY formula.
20%至40%的糖尿病患者会发展为糖尿病肾病，糖尿病肾病患者需要透析和肾移植。中医在中国已广泛用于治疗糖尿病肾病患者。然而，中医的具体机制仍不清楚。益气养阴化瘀通络方（ZY方）是一种中药方剂。在此，我们证明了ZY方对糖尿病肾病大鼠具有肾脏保护作用。ZY方对糖尿病肾病的治疗效果与厄贝沙坦几乎相同，厄贝沙坦已被证明对糖尿病肾病有极佳的疗效。我们还阐明了ZY方对糖尿病肾病的作用机制。首先，我们证实ZY可降低糖尿病大鼠体内ROS-JNK信号通路的激活。此外，ZY方治疗可下调I型胶原蛋白的表达。同时，ZY方可减轻糖尿病大鼠肾脏中的细胞凋亡。
