Department of Medical Research (Pyin Oo Lwin Branch), Ministry of Health and Sports, Pyin Oo Lwin, Mandalay Region, Myanmar.
Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Am J Trop Med Hyg. 2019 Mar;100(3):643-646. doi: 10.4269/ajtmh.18-0530.
This study was conducted to find the burden of dengue virus (DENV) and Japanese encephalitis virus (JEV) among children under the age of 13, who presented with acute encephalitis syndrome at Mandalay Children Hospital in Myanmar in 2013. Molecular and serological investigations were performed on 123 cerebrospinal fluid (CSF) samples collected from these patients. By neutralization tests and/or virus isolation, four (3.3%) JEV- and one DENV-associated encephalitis cases (0.8%) were confirmed. Antibody titer against JEV Genotype 3 was the highest among the laboratory-confirmed JEV cases. One strain of DENV-1 with Genotype 1 was isolated from the CSF sample of the dengue encephalitis patient; this was similar to the virus circulating in the study area and neighboring countries. This study shows that flaviviruses are important pathogens causing encephalitis in Myanmar. Active disease surveillance, vector control, and vaccination programs should be enforced to reduce the morbidity and mortality caused by flavivirus encephalitis.
本研究旨在调查缅甸仰光儿童医院 2013 年收治的 123 例急性脑炎综合征患儿的登革热病毒（DENV）和日本脑炎病毒（JEV）负担。对这些患者的 123 份脑脊液（CSF）样本进行了分子和血清学调查。通过中和试验和/或病毒分离，确认了四例（3.3%）JEV 相关脑炎和一例 DENV 相关脑炎病例（0.8%）。在实验室确诊的 JEV 病例中，针对 JEV 基因型 3 的抗体滴度最高。从登革热脑炎患者的 CSF 样本中分离出一株 DENV-1 株，与该地区和邻国流行的病毒相似。本研究表明，黄病毒是导致缅甸脑炎的重要病原体。应加强疾病监测、病媒控制和疫苗接种计划，以降低黄病毒脑炎的发病率和死亡率。
