Alisjahbana Dewi Hawani, Nurmawati Syndi, Hakim Dzulfikar Dl, Milanti Mia, Dewi Yora Permata, Johar Edison, Myint Khin Saw Aye, Lederman Jeremy P, Powers Ann M, Alisjahbana Bachti, Antonjaya Ungke
Department of Child Health, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia.
SAGE Open Med Case Rep. 2021 Jul 23;9:2050313X211034393. doi: 10.1177/2050313X211034393. eCollection 2021.
Central nervous system involvement of dengue virus is increasingly reported from endemic areas. This study describes the clinical characteristics and laboratory features of a pediatric patient enrolled in a central nervous system illness study conducted in 2017-2018 to identify viral and bacterial etiologies in Indonesian children. Dengue diagnostics including molecular and serological testing were performed on an encephalitis patient who presented with both classical dengue and neurological clinical symptoms. Dengue virus serotype 1 RNA was detected in both cerebrospinal fluid and serum by serotype-specific reverse transcription polymerase chain reaction, and the E gene was successfully sequenced. Anti-dengue virus immunoglobulin M was detected in both admission and discharge sera, whereas anti-dengue virus immunoglobulin G was identified only in the discharge serum. This study describes the central nervous system complications in a case with dengue virus infection in West Java, Indonesia, and highlights the potential for dengue virus serotype 1, a serotype rarely associated with neurotropism, to cause encephalitis.
来自流行地区的登革热病毒中枢神经系统受累的报道日益增多。本研究描述了一名参与2017 - 2018年进行的中枢神经系统疾病研究的儿科患者的临床特征和实验室检查结果，该研究旨在确定印度尼西亚儿童的病毒和细菌病因。对一名同时出现典型登革热和神经临床症状的脑炎患者进行了包括分子和血清学检测在内的登革热诊断。通过血清型特异性逆转录聚合酶链反应在脑脊液和血清中均检测到登革热病毒1型RNA，并成功对E基因进行了测序。入院和出院血清中均检测到抗登革热病毒免疫球蛋白M，而抗登革热病毒免疫球蛋白G仅在出院血清中检测到。本研究描述了印度尼西亚西爪哇一名登革热病毒感染病例的中枢神经系统并发症，并强调了很少与嗜神经性相关的登革热病毒1型导致脑炎的可能性。
