三齿豹皮樟素 A 和 B，三齿豹皮樟子实体中的抗炎性萜类化合物。
Tricholopardins A and B, Anti-inflammatory Terpenoids from the Fruiting Bodies of Tricholoma pardinum.
机构信息
School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan 430074 , People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany , Kunming 650201 , People's Republic of China.
出版信息
J Nat Prod. 2019 Jan 25;82(1):45-50. doi: 10.1021/acs.jnatprod.8b00460. Epub 2019 Jan 10.
Two new Tricholoma terpenoids, tricholopardins A and B, were isolated from the fruiting bodies of the basidiomycetes Tricholoma pardinum. Their structures were elucidated by spectroscopic methods, as well as electronic circular dichroism and optical rotatory dispersion calculations. Tricholopardin A potently inhibited nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages with an IC of 0.08 μM. Its anti-inflammatory effects on three inflammatory mediators were also evaluated. A plausible biosynthetic pathway for these products is discussed.
两种新的 Tricholoma 萜类化合物，即 tricholopardin A 和 B，从担子菌 Tricholoma pardinum 的子实体中分离得到。通过光谱方法以及电子圆二色性和旋光色散计算阐明了它们的结构。Tricholopardin A 对脂多糖诱导的 RAW264.7 巨噬细胞中一氧化氮的产生具有很强的抑制作用，IC 为 0.08 μM。还评估了其对三种炎症介质的抗炎作用。讨论了这些产物的可能生物合成途径。
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