Mekonnen Hailemichael Desalegn, Fisseha Henok, Getinet Tewodros, Tekle Fisseha, Galle Peter R
Medical Department, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Myungsung Christian Medical Center, Addis Ababa, Ethiopia.
Int J Hepatol. 2018 Dec 2;2018:1941728. doi: 10.1155/2018/1941728. eCollection 2018.
Hepatocellular carcinoma is a major cause of cancer death worldwide, accounting for over half a million deaths per year. Its incidence varies with geographic locations and the type of etiologic factors. In Ethiopia, unidentified causes of liver disease are of sizeable proportion. Recent studies have shown an association of H. pylori infection with different spectrums of chronic liver disease. This study was conducted at St. Paul's Hospital Millennium Medical College in Ethiopia and assesses liver cancer and the association with H. pylori infection. A prospective case-control study conducted on patients with chronic liver disease presenting with a suspicious liver lesion and diagnosed to have HCC in the Gastrointestinal (GI) Clinic of St. Paul's Hospital MMC from Dec 30, 2016, to Nov 1, 2017 G.C. Descriptive surveys on clinical history and physical examination and laboratory profiles were obtained, and the clinical course of the patients including the type of treatment was followed prospectively. Control cases were taken from adult patients without evidence of liver disease in the internal medicine clinic coming for routine evaluation. After collection data were analyzed using SPSS version 23 and associations were assessed using chi-square test. Binary logistic regression was used to assess the association of HCC with different variables and H. pylori infection. All variables with p-value <0.05 were considered as statistically significant. One hundred twenty patients were analyzed with equal representation of cases and controls. The majority of patients with HCC were male with a mean age of 36 years. Older age adjusted Odds Ratio (AOR) (95%CI, p-value) 1.07(1.03-1.09, <0.001), viral hepatitis B (AOR) (95%CI, p-value) 6.19 (1.92-19.93, 0.002), and H. pylori infection (AOR) (95%CI, p-value) 5.22 (2.04-13.31, <0.001) were statistically significantly associated with HCC. H. pylori infection is associated with HCC in this case-control study. This study supports the emerging evidence of H. pylori association with other extra-gastric manifestations.
肝细胞癌是全球癌症死亡的主要原因，每年导致超过50万人死亡。其发病率因地理位置和病因类型而异。在埃塞俄比亚，不明原因的肝病占相当大的比例。最近的研究表明，幽门螺杆菌感染与不同类型的慢性肝病有关。本研究在埃塞俄比亚的圣保罗医院千禧医学院进行，评估肝癌及其与幽门螺杆菌感染的关联。对2016年12月30日至2017年11月1日在圣保罗医院MMC胃肠病诊所出现可疑肝脏病变并被诊断为肝癌的慢性肝病患者进行了一项前瞻性病例对照研究。收集了临床病史、体格检查和实验室检查结果的描述性调查资料，并对患者的临床病程（包括治疗类型）进行了前瞻性跟踪。对照病例来自内科诊所前来进行常规评估且无肝病证据的成年患者。收集数据后，使用SPSS 23版进行分析，并使用卡方检验评估相关性。采用二元逻辑回归分析肝癌与不同变量及幽门螺杆菌感染之间的关联。所有p值<0.05的变量均被视为具有统计学意义。共分析了120例患者，病例组和对照组人数相等。大多数肝癌患者为男性，平均年龄36岁。年龄较大（调整优势比[AOR]（95%置信区间，p值）1.07[1.03 - 1.09，<0.001]）、乙型病毒性肝炎（AOR）（95%置信区间，p值）6.19（1.92 - 19.93，0.002）和幽门螺杆菌感染（AOR）（95%置信区间，p值）5.22（2.04 - 13.31，<0.001）与肝癌在统计学上显著相关。在本病例对照研究中，幽门螺杆菌感染与肝癌有关。本研究支持了幽门螺杆菌与其他胃外表现相关的新证据。
