Sprecher E, Becker Y
Department of Molecular Virology, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Arch Virol. 1988;103(1-2):1-14. doi: 10.1007/BF01319804.
Langerhans cells function as highly potent antigen-presenting cells in the epidermis. In the last few years, their role in viral infections has been studied in various experimental systems. They have been shown to be involved in the pathogenesis of a number of infections of viral origin. These include vaccinia virus, human papilloma virus, herpes simplex virus, foot and mouth disease virus and human retrovirus infections. Studies on the effect of various factors, that are known to modulate the activity and density of Langerhans cell in the epidermis, may lead in the future to the development of new strategies aimed at inhibiting virus infections or even eradicating latent infection.
朗格汉斯细胞在表皮中作为高效的抗原呈递细胞发挥作用。在过去几年里，它们在病毒感染中的作用已在各种实验系统中得到研究。已表明它们参与多种病毒源性感染的发病机制。这些感染包括牛痘病毒、人乳头瘤病毒、单纯疱疹病毒、口蹄疫病毒和人类逆转录病毒感染。对各种已知可调节表皮中朗格汉斯细胞活性和密度的因素的研究，未来可能会导致开发出新的策略，旨在抑制病毒感染甚至根除潜伏感染。
