Faculty of Medical Sciences, Department of Pharmacy, University of Kragujevac, Kragujevac, Serbia.
Faculty of Medical Sciences, Department of Physiology, University of Kragujevac, Kragujevac, Serbia.
Arch Physiol Biochem. 2020 Dec;126(5):408-415. doi: 10.1080/13813455.2018.1551904. Epub 2019 Jan 11.
The aim of our study was to determine a chemical composition of methanol extract of as well as to assess its effects on functional recovery and redox status of isolated rat heart after ischemia. Rats were divided into control and group, which included animals treated with 500 mg/kg of methanol extract of for 28 days. Parameters of heart function and oxidative stress markers were estimated. Cell morphology was evaluated by hematoxylin and eosin (HE) staining. Our results demonstrated for the first time that extract preserved cardiac contractility, systolic, and diastolic function as wells as structural damage of the heart after ischemia. Furthermore, extract modulated the activity of antioxidant enzymes and alleviated the production of pro-oxidants.
我们研究的目的是确定 甲醇提取物的化学成分，并评估其对缺血后分离大鼠心脏功能恢复和氧化还原状态的影响。将大鼠分为对照组和 组，其中 组包括用 500mg/kg 的 甲醇提取物处理 28 天的动物。评估了心脏功能参数和氧化应激标志物。通过苏木精和伊红（HE）染色评估细胞形态。我们的结果首次表明， 提取物在缺血后保持了心脏的收缩性、收缩和舒张功能以及心脏的结构损伤。此外， 提取物调节了抗氧化酶的活性并减轻了促氧化剂的产生。
