肿瘤芽分级作为早期舌鳞癌独立预后因素的重要性。
Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma.
机构信息
Department of Head and Neck Surgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
出版信息
Head Neck. 2019 Jun;41(6):1809-1815. doi: 10.1002/hed.25614. Epub 2019 Jan 11.
BACKGROUND
Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown.
METHODS
We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC.
RESULTS
Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80-50.8; P = .008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34-14.5; P = .02).
CONCLUSION
The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.
背景
颈部淋巴结转移（NLM）和早期舌鳞状细胞癌（SCC）的预后相关因素尚不清楚。
方法
我们分析了 64 例 cT1/2N0 舌 SCC 患者的疾病特异性生存（DSS）和包括肿瘤芽分级（TBG）在内的 NLM。
结果
对原发灶 DSS 的单因素分析发现新 cT、pT、新 pT、p 直径、静脉浸润和 TBG 有显著差异。多因素分析仅选择 TBG3 作为 NLM（优势比，9.55；95%置信区间 [CI]，1.80-50.8；P=0.008）和 DSS（风险比，4.41；95% CI，1.34-14.5；P=0.02）的预测因素。
结论
NLM 和早期舌 SCC 的唯一预测因素是 TBG，表明它可能有助于选择风险较大的患者。
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