Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Viruses. 2019 Jan 10;11(1):46. doi: 10.3390/v11010046.
Influenza A Virus (IAV) is a respiratory virus that causes seasonal outbreaks annually and pandemics occasionally. The main targets of the virus are epithelial cells in the respiratory tract. Like many other viruses, IAV employs the host cell's machinery to enter cells, synthesize new genomes and viral proteins, and assemble new virus particles. The cytoskeletal system is a major cellular machinery, which IAV exploits for its entry to and exit from the cell. However, in some cases, the cytoskeleton has a negative impact on efficient IAV growth. In this review, we highlight the role of cytoskeletal elements in cellular processes that are utilized by IAV in the host cell. We further provide an in-depth summary of the current literature on the roles the cytoskeleton plays in regulating specific steps during the assembly of progeny IAV particles.
甲型流感病毒（IAV）是一种呼吸道病毒，每年都会引起季节性爆发，偶尔也会引起大流行。该病毒的主要靶标是呼吸道中的上皮细胞。与许多其他病毒一样，IAV 利用宿主细胞的机制进入细胞，合成新的基因组和病毒蛋白，并组装新的病毒颗粒。细胞骨架系统是一种主要的细胞机制，IAV 利用它进入和离开细胞。然而，在某些情况下，细胞骨架会对 IAV 的有效生长产生负面影响。在这篇综述中，我们强调了细胞骨架在 IAV 在宿主细胞中利用的细胞过程中的作用。我们进一步深入总结了细胞骨架在调节子代 IAV 颗粒组装过程中特定步骤的作用的当前文献。
