Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Lleida, Spain.
Department of Pathology and Experimental Therapeutics, University of Barcelona; Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.
Redox Biol. 2019 May;23:101082. doi: 10.1016/j.redox.2018.101082. Epub 2018 Dec 19.
The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that sustain the preservation or deterioration of neurons and cerebral functions are unknown. In this review, we focus attention on the role of lipids and the importance of the cross-regionally different vulnerabilities in human brain aging. In particular, we first consider a brief approach to the lipidomics of human brain, the relationship between lipids and lipoxidative damage, the role of lipids in human brain aging, and the specific targets of lipoxidative damage in human brain and during aging. It is proposed that the restricted set of modified proteins and the functional categories involved may be considered putative collaborative factors contributing to neuronal aging, and that mitochondrial ATP synthase is a key lipoxidative target in human brain aging.
人类大脑像人体其他细胞系统一样，是衰老过程的目标。人类大脑的特定区域表现出对衰老过程的不同脆弱性。然而，维持神经元和大脑功能的保存或恶化的潜在机制尚不清楚。在这篇综述中，我们关注脂质的作用以及人类大脑衰老中跨区域不同脆弱性的重要性。特别是，我们首先考虑简要探讨人类大脑的脂质组学、脂质与脂质氧化损伤的关系、脂质在人类大脑衰老中的作用以及人类大脑和衰老过程中脂质氧化损伤的特定靶点。有人提出，受限制的修饰蛋白质组和涉及的功能类别可以被认为是导致神经元衰老的潜在协同因素，而线粒体 ATP 合酶是人类大脑衰老中的关键脂质氧化靶点。
