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慢性牙周炎患者和健康受试者龈沟液中骨硬化蛋白的水平。

Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects.

作者信息

Rezaei Esfahrood Zeinab, Yadegari Zahra, Veysari Setareh Kazemi, Kadkhodazadeh Mahdi

机构信息

Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Dental Biomaterials, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

J Korean Assoc Oral Maxillofac Surg. 2018 Dec;44(6):289-292. doi: 10.5125/jkaoms.2018.44.6.289. Epub 2018 Dec 28.

DOI:10.5125/jkaoms.2018.44.6.289
PMID:30637243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6327015/
Abstract

OBJECTIVES

Chronic periodontitis is a common inflammatory disease of the oral cavity that causes destruction of periodontal tissues and bone around the teeth. Sclerostin is a protein encoded by the gene. In this study, gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis were compared with those of healthy subjects.

MATERIALS AND METHODS

In this case-control study, a total of 40 subjects were enrolled and divided into the healthy group (n=23) and chronic periodontitis group (n=17). GCF samples were collected, and the concentration of sclerostin was evaluated using enzyme-linked immunosorbent assay. Comparison of significance between groups was assessed using Mann-Whitney U test.

RESULTS

Sclerostin concentration was significantly higher in the chronic periodontitis group compared with the healthy group (<0.005).

CONCLUSION

Despite the limitations of this study, sclerostin can be a possible marker for assessment of periodontal health status.

摘要

目的

慢性牙周炎是一种常见的口腔炎症性疾病，会导致牙齿周围的牙周组织和骨质破坏。硬化蛋白是由该基因编码的一种蛋白质。在本研究中，对慢性牙周炎患者龈沟液（GCF）中硬化蛋白的水平与健康受试者进行了比较。

材料与方法

在这项病例对照研究中，共纳入40名受试者，分为健康组（n = 23）和慢性牙周炎组（n = 17）。收集GCF样本，并使用酶联免疫吸附测定法评估硬化蛋白的浓度。采用曼-惠特尼U检验评估组间差异的显著性。

结果

与健康组相比，慢性牙周炎组的硬化蛋白浓度显著更高（<0.005）。

结论

尽管本研究存在局限性，但硬化蛋白可能是评估牙周健康状况的一个标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d710/6327015/10bfb85388a4/jkaoms-44-289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d710/6327015/10bfb85388a4/jkaoms-44-289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d710/6327015/10bfb85388a4/jkaoms-44-289-g001.jpg

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WNT-5a and SOST Levels in Gingival Crevicular Fluid Depend on the Inflammatory and Osteoclastogenic Activities of Periodontal Tissues.龈沟液中 WNT-5a 和 SOST 水平取决于牙周组织的炎症和破骨细胞活性。
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