The Guangdong Province Key Laboratory for Aquatic Economic Animals, School of Life Science, Sun Yat-sen University, Guangzhou, China.
Chemical Drugs Department, Guangdong Institute for Food and Drug Control, Guangzhou, China.
Nat Prod Res. 2020 Apr;34(8):1105-1112. doi: 10.1080/14786419.2018.1550762. Epub 2019 Jan 12.
A novel aromatic compound, grandiuvarone B (5-acetoxy-3-benzoyloxymethyl-5H-oxepin-4-one), along with a known compound grandiuvarone A (5-acetoxy-6-benzoyloxymethyl-5H-oxepin-4-one) were isolated from methanol extracts of leaves. Their structures were determined by various spectroscopic techniques including nuclear magnetic resonance (NMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). Grandiuvarone A and grandiuvarone B are isomers and the configuration of grandiuvarone B was reported for the first time. We then determined their antifungal activity against . Results revealed that grandiuvarone B exhibited better antifungal activity against , with MIC values of 0.01 mg/mL compared to grandiuvarone A (MIC values of 0.02 mg/mL). In the presence of each active compound at 160 μg/g of aquafeed, growth was completely inhibited. Grandiuvarone B also showed antibacterial activity against the plant pathogen .
从叶片的甲醇提取物中分离得到了一种新的芳香族化合物，大香叶素 B（5-乙酰氧基-3-苯甲酰氧甲基-5H-氧杂环庚-4-酮），以及一种已知化合物大香叶素 A（5-乙酰氧基-6-苯甲酰氧甲基-5H-氧杂环庚-4-酮）。它们的结构通过各种光谱技术确定，包括核磁共振（NMR）、高分辨率电喷雾电离质谱（HR-ESI-MS）和圆二色性（CD）。大香叶素 A 和大香叶素 B 是同分异构体，大香叶素 B 的 构型是首次报道的。然后，我们测定了它们对 的抗真菌活性。结果表明，大香叶素 B 对 的抗真菌活性更好，MIC 值为 0.01 mg/mL，而大香叶素 A 的 MIC 值为 0.02 mg/mL。在 160 μg/g 的水产饲料中添加每种活性化合物时， 的生长完全受到抑制。大香叶素 B 还对植物病原菌 表现出抗菌活性。
