The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, School of Pharmacy, University of Washington, Seattle, WA; The Departments of Health Services and Economics, University of Washington, Seattle, WA.
The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, School of Pharmacy, University of Washington, Seattle, WA.
Am Heart J. 2019 Mar;209:116-125. doi: 10.1016/j.ahj.2018.12.003. Epub 2018 Dec 8.
A research funder faces the challenge of selecting to fund a small set of studies from a larger pool of proposals, even after proposals achieve the benchmarks of scientific rigor and integrity. Clinical researchers can better quantify the value of their proposed study to facilitate this prioritization process. Value of information (VOI) analysis, can help in this quantification and inform the funder about the population and individual patient-level impact of a comparative research proposal. In this paper, we introduce the overarching framework of the value of information to a clinical research audience, identify the steps required to calculate VOI for a proposal, and highlight some software that can be used to readily compute these estimates based on information available for a research protocol.
研究资助者面临着从大量提案中选择资助一小部分研究的挑战，即使提案已经达到了科学严谨性和完整性的基准。临床研究人员可以更好地量化他们提出的研究的价值，以促进这一优先排序过程。信息价值（VOI）分析可以帮助进行这种量化，并向资助者提供比较研究提案对人群和个体患者的影响。在本文中，我们向临床研究界介绍了信息价值的总体框架，确定了计算提案 VOI 所需的步骤，并强调了一些可以根据研究方案中可用的信息来快速计算这些估计值的软件。
