Division of Research, Kaiser Permanente Northern California, Oakland, USA.
Division of Research, Kaiser Permanente Northern California, Oakland, USA.
J Cataract Refract Surg. 2019 Apr;45(4):404-413. doi: 10.1016/j.jcrs.2018.11.002. Epub 2019 Jan 9.
To assess the relation between diabetic retinopathy (DR) severity, duration of diabetes, insulin dependence, and preoperative hemoglobin A (HbA) with visual outcome after phacoemulsification for cataract in patients with type 2 diabetes.
Kaiser Permanente Northern California, USA.
Retrospective case series.
Information was obtained from the electronic medical record for patients, June 1, 2010, through May 31, 2015. Confounding factors and clustering of eyes within patients were controlled for using linear mixed-effects regression models for continuous outcomes and general estimating equations for dichotomous outcomes.
The study included 65 370 patients; 28% had type 2 diabetes without DR, 5% nonproliferative DR, and 1.2% proliferative DR. Patients with diabetes and no DR were as likely as those without diabetes to achieve a corrected distance visual acuity (CDVA) of 20/20 (odds ratio, 1.01; 95% confidence interval, 0.94-1.10). The odds of a postoperative CDVA of 20/25 or worse increased with the severity of retinopathy duration of diabetes and insulin dependence, but not with the preoperative HbA. Although the odds of a postoperative CDVA of 20/20 was lower in patients with DR, every DR group averaged 4 lines of CDVA improvement, the same as patients without diabetes. A longer duration of diabetes, insulin dependence, and elevated HbA were not associated with worse postoperative outcomes.
Patients with DR and cataracts were less likely to achieve a CDVA of 20/20 vision but gained as many lines of CDVA from phacoemulsification as patients without diabetes, showing no evidence that cataract surgery should be delayed in diabetic patients with elevated HbA.
评估 2 型糖尿病患者白内障超声乳化术后视力结果与糖尿病视网膜病变(DR)严重程度、糖尿病病程、胰岛素依赖以及术前糖化血红蛋白(HbA)之间的关系。
美国北加州 Kaiser 永久医疗集团。
回顾性病例系列研究。
研究数据来源于 2010 年 6 月 1 日至 2015 年 5 月 31 日的电子病历。采用线性混合效应回归模型分析连续变量,广义估计方程分析二分类变量,对混杂因素和患者内眼别进行校正。
共纳入 65370 例患者,其中 28%无 DR,5%为非增殖性 DR,1.2%为增殖性 DR。无 DR 的糖尿病患者与非糖尿病患者术后达到 20/20 视力的可能性相似(优势比 1.01;95%置信区间 0.94-1.10)。术后视力为 20/25 或更差的风险随着 DR 严重程度、糖尿病病程和胰岛素依赖程度的增加而增加,但与术前 HbA 无关。虽然 DR 患者术后达到 20/20 视力的可能性较低,但每个 DR 组的平均视力改善均为 4 行,与非糖尿病患者相同。较长的糖尿病病程、胰岛素依赖和 HbA 升高与术后结局不佳无关。
DR 合并白内障患者术后达到 20/20 视力的可能性较低,但与非糖尿病患者一样,白内障超声乳化术后视力均有改善,HbA 升高的糖尿病患者不应延迟白内障手术。