细胞毒性T细胞将雄性抗原和H-2识别为不同的实体。
Cytotoxic T cells recognize male antigen and H-2 as distinct entities.
作者信息
von Boehmer H, Haas W, Pohlit H
出版信息
J Exp Med. 1978 Apr 1;147(4):1291-5. doi: 10.1084/jem.147.4.1291.
Abstract
XX cells from XX/XY hemopoietic chimeras do not express male determinants in a way to render them either stimulators or targets for male-specific cytotoxic lymphocytes. XX- but not XY-responder T cells from chimeras can be activated to lyse allogeneic male target cells; T cells from normal XX mice depleted of alloreactive T cells, however, cannot be sensitized to lyse allogeneic XY targets. The results imply that T cells recognize the Y-antigen and H-2 as distinct entities, and that in chimeras, they acquire the potential to react against allogeneic XY cells.
摘要
来自XX/XY造血嵌合体的XX细胞不会以使其成为雄性特异性细胞毒性淋巴细胞的刺激物或靶标的方式表达雄性决定因素。嵌合体中XX反应性T细胞（而非XY反应性T细胞）可被激活以裂解同种异体雄性靶细胞；然而，来自正常XX小鼠且去除了同种异体反应性T细胞的T细胞不能被致敏以裂解同种异体XY靶细胞。这些结果表明，T细胞将Y抗原和H-2识别为不同的实体，并且在嵌合体中，它们获得了对抗同种异体XY细胞的潜力。
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