Research Institute, Genencell Co. Ltd., Yongin 16950, Korea.
Biodiversity Research Institute, Jeju Technopark, Namwon 63608, Jeju, Korea.
Molecules. 2019 Jan 13;24(2):276. doi: 10.3390/molecules24020276.
(1) : Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular damage and functional loss. It is characterized by synovial inflammation that leads to progressive cartilage destruction. For this reason, research on functional foods that reduce the inflammatory response are under progress. (2) : We focused on the anti-inflammatory effects of , and confirmed the effect of the extract on the collagen-induced arthritis (CIA) DBA/1J mice model. (3) : The extract was given at concentrations of 50, 100, and 200 mg/kg, and the arthritis score and edema volume of the experimental group were significantly different from the CIA group. The level of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ were determined in serum and lymphocytes. The expression of these cytokines in the serum remarkably decreased from extract (SME)100 mg/kg, and decreased from SME 200 mg/kg in lymphocytes. Also, immunohistochemical analysis of IL-6 and TNF-α in the joints revealed that the inflammatory response was noticeably lower when treated with extract. (4) : This study provides results of the experiment of extract treatment in a mouse model. The treatment was found to contribute to the alleviation of edema and symptoms by reducing the expression of inflammatory cytokines. It was concluded that it may be a useful substance to help in the mitigation of arthritis symptoms.
(1) 类风湿关节炎是一种慢性自身免疫性疾病，可导致进行性关节损伤和功能丧失。其特征为滑膜炎症，进而导致进行性软骨破坏。因此，正在研究具有减轻炎症反应的功能性食品。
(2) 我们专注于[化合物名称]的抗炎作用，并在胶原诱导性关节炎（CIA）DBA/1J 小鼠模型中证实了提取物的作用。
(3) 以 50、100 和 200mg/kg 的浓度给予提取物，实验组的关节炎评分和肿胀体积与 CIA 组有显著差异。在血清和淋巴细胞中测定白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α 和干扰素（IFN）-γ的水平。从 SME100mg/kg 的提取物中显著降低了这些细胞因子在血清中的表达，从 SME200mg/kg 的提取物中降低了淋巴细胞中的表达。此外，关节中 IL-6 和 TNF-α 的免疫组织化学分析表明，用提取物治疗时炎症反应明显降低。
(4) 本研究提供了在小鼠模型中用提取物进行治疗的实验结果。治疗可通过减少炎症细胞因子的表达来减轻水肿和症状，因此可得出结论，它可能是一种有助于缓解关节炎症状的有用物质。
