Bhat Anusha Ganapati, Siddappa Malleshappa Sudeep K, Pasupula Deepak Kumar, Duke Wayne, Shaaban Reham
Internal Medicine, Baystate Medical Center, Springfield, USA.
Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA.
Cureus. 2018 Oct 24;10(10):e3490. doi: 10.7759/cureus.3490.
Bullous variant of Sweet's syndrome (SS) is a rare form of SS, which clinically presents as bullous hemorrhagic rash and demonstrates dermal neutrophilic infiltrates with segregation of dermo-epidermal junction histopathologically. We present a case of a 73-year-old patient, who initially developed a hypersensitivity reaction on exposure to a radiocontrast agent and subsequently developed blistering rashes, which were established to be from bullous SS after exclusion of other possible diagnoses. Contrast media are utilized commonly in the current era of medicine and SS is rarely identified as an adverse event from it. Bullous variant particularly presents aggressively, which when recognized early responds to steroid use with clinical recovery.
斯威特综合征(SS)的大疱性变种是SS的一种罕见形式,临床上表现为大疱性出血性皮疹,组织病理学显示真皮有嗜中性粒细胞浸润且真皮-表皮交界处分离。我们报告一例73岁患者,该患者最初在接触放射性造影剂后发生过敏反应,随后出现水疱性皮疹,在排除其他可能诊断后确诊为大疱性SS。在当今医学时代,造影剂被广泛使用,而SS很少被认定为其不良事件。大疱性变种尤其表现得较为严重,早期识别后使用类固醇治疗可实现临床康复。