Center of Digital Dentistry, Peking University School and Hospital of Stomatology, Beijing, China.
National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing, China.
Tissue Eng Part A. 2019 Sep;25(17-18):1261-1271. doi: 10.1089/ten.TEA.2018.0201. Epub 2019 Jun 14.
Bone loss due to trauma, inflammation, and surgical processes has posed great difficulty in the aesthetic reconstruction of a functional alveolar bone. Tissue engineering and biomaterials, which can promote alveolar bone regeneration, have become a popular focus of current studies. Three-dimensional (3D) printing provides a novel approach to repair bone defects using customized biomimetic tissue scaffolds. Nano hydroxyapatite (nHA) and deproteinized bovine bone (DBB) are two materials mainly used in clinical practice, particularly DBB are widely used in dentistry and craniomaxillofacial orthosis because of the porosity characteristic. To make a bone substitute closest to natural bone structure and composition, nHA and DBB were dispersed into collagen (CoL) to prepare the bioink for 3D printing. The physicochemical and biological properties between the two 3D printing scaffolds were compared. Both nHA/CoL and DBB/CoL 3D printing scaffold would be promising candidate for the clinical applications in the future.
创伤、炎症和手术过程导致的骨丢失给功能性牙槽骨的美学重建带来了极大的困难。能够促进牙槽骨再生的组织工程和生物材料已成为当前研究的热门焦点。三维（3D）打印为使用定制仿生组织支架修复骨缺损提供了一种新方法。纳米羟基磷灰石（nHA）和脱蛋白牛骨（DBB）是两种主要用于临床实践的材料，尤其是 DBB 由于其多孔特性，在牙科和颅颌面矫形中得到了广泛应用。为了制造最接近天然骨结构和组成的骨替代物，将 nHA 和 DBB 分散到胶原蛋白（CoL）中，以制备用于 3D 打印的生物墨水。比较了两种 3D 打印支架的理化和生物学特性。nHA/CoL 和 DBB/CoL 3D 打印支架都将是未来临床应用的有前途的候选者。
