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太空环境中骨髓重塑与免疫功能障碍的体外模型：现状与未来方向

In Vitro Models of Bone Marrow Remodelling and Immune Dysfunction in Space: Present State and Future Directions.

作者信息

Sarkar Ryan, Pampaloni Francesco

机构信息

Buchmann Institute for Molecular Life Sciences (BMLS), Johann Wolfgang Goethe Universität, 60438 Frankfurt am Main, Germany.

出版信息

Biomedicines. 2022 Mar 24;10(4):766. doi: 10.3390/biomedicines10040766.

DOI:10.3390/biomedicines10040766
PMID:35453515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9031916/
Abstract

Spaceflight affects the body on every level. Reports on astronaut health identify bone marrow remodelling and dysfunction of the innate immune system as significant health risks of long-term habitation in space. Microgravity-induced alterations of the bone marrow induce physical changes to the bone marrow stem cell niche. Downstream effects on innate immunity are expected due to impaired hematopoiesis and myelopoiesis. To date, few studies have investigated these effects in real microgravity and the sparsely available literature often reports contrasting results. This emphasizes a need for the development of physiologically relevant in vitro models of the bone marrow stem cell niche, capable of delivering appropriate sample sizes for robust statistics. Here, we review recent findings on the impact of spaceflight conditions on innate immunity in in vitro and animal models and discusses the latest in vitro models of the bone marrow stem cell niche and their potential translatability to gravitational biology research.

摘要

太空飞行会在各个层面影响人体。关于宇航员健康的报告指出，骨髓重塑和先天免疫系统功能障碍是长期居住在太空的重大健康风险。微重力引起的骨髓改变会导致骨髓干细胞生态位发生物理变化。由于造血和骨髓生成受损，预计会对先天免疫产生下游影响。迄今为止，很少有研究在真实的微重力环境中研究这些影响，而且现有的少量文献往往报道了相互矛盾的结果。这凸显了开发与生理相关的骨髓干细胞生态位体外模型的必要性，该模型能够提供合适的样本量以进行可靠的统计分析。在这里，我们回顾了太空飞行条件对体外和动物模型中先天免疫影响的最新研究结果，并讨论了骨髓干细胞生态位的最新体外模型及其在引力生物学研究中的潜在可转化性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/12528f80ef78/biomedicines-10-00766-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/136ae3e2b041/biomedicines-10-00766-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/d5b974be47a8/biomedicines-10-00766-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/ea7d0a4673d3/biomedicines-10-00766-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/3f344a87bd67/biomedicines-10-00766-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/058c207d955d/biomedicines-10-00766-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/12528f80ef78/biomedicines-10-00766-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/136ae3e2b041/biomedicines-10-00766-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/d5b974be47a8/biomedicines-10-00766-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/ea7d0a4673d3/biomedicines-10-00766-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/3f344a87bd67/biomedicines-10-00766-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/058c207d955d/biomedicines-10-00766-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d913/9031916/12528f80ef78/biomedicines-10-00766-g006.jpg

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