前瞻性研究母亲胆碱状态与两个大型母婴队列（南安普顿妇女调查队列和新加坡成长至健康结局队列）中儿童生命最初 5 年身体成分的关系。
Prospective associations of maternal choline status with offspring body composition in the first 5 years of life in two large mother-offspring cohorts: the Southampton Women's Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort.
机构信息
Singapore Institute for Clinical Science, Agency for Science, Technology, and Research, Singapore.
MRC Lifecourse Epidemiology Unit, University of Southampton, UK.
出版信息
Int J Epidemiol. 2019 Apr 1;48(2):433-444. doi: 10.1093/ije/dyy291.
BACKGROUND
Choline status has been positively associated with weight and fat mass in animal and human studies. As evidence examining maternal circulating choline concentrations and offspring body composition in human infants/children is lacking, we investigated this in two cohorts.
METHODS
Maternal choline concentrations were measured in the UK Southampton Women's Survey (SWS; serum, n = 985, 11 weeks' gestation) and Singapore Growing Up Towards healthy Outcomes (GUSTO); n = 955, 26-28 weeks' gestation) mother-offspring cohorts. Offspring anthropometry was measured at birth and up to age 5 years. Body fat mass was determined using dual-energy x-ray absorptiometry at birth and age 4 years for SWS; and using air-displacement plethysmography at birth and age 5 years for GUSTO. Linear-regression analyses were performed, adjusting for confounders.
RESULTS
In SWS, higher maternal choline concentrations were associated with higher neonatal total body fat mass {β = 0.60 standard deviation [SD]/5 µmol/L maternal choline [95% confidence interval (CI) 0.04-1.16]} and higher subscapular skinfold thickness [β = 0.55 mm/5 µmol/L (95% CI, 0.12-1.00)] at birth. In GUSTO, higher maternal choline concentrations were associated with higher neonatal body mass index-for-age z-score [β = 0.31 SD/5 µmol/L (0.10-0.51)] and higher triceps [β = 0.38 mm/5 µmol/L (95% CI, 0.11-0.65)] and subscapular skinfold thicknesses [β = 0.26 mm/5 µmol/L (95% CI, 0.01-0.50)] at birth. No consistent trends were observed between maternal choline and offspring gain in body mass index, skinfold thicknesses, abdominal circumference, weight, length/height and adiposity measures in later infancy and early childhood.
CONCLUSION
Our study provides evidence that maternal circulating choline concentrations during pregnancy are positively associated with offspring BMI, skinfold thicknesses and adiposity at birth, but not with growth and adiposity through infancy and early childhood to the age of 5 years.
背景
胆碱状态与动物和人类研究中的体重和脂肪量呈正相关。由于缺乏关于母体循环胆碱浓度与人类婴儿/儿童后代身体成分的证据，我们在两个队列中对此进行了研究。
方法
在英国南安普顿妇女调查（SWS；血清，n=985，11 周妊娠）和新加坡成长为健康结局（GUSTO）；n=955，26-28 周妊娠）母亲-后代队列中测量了母体胆碱浓度。在出生时和 5 岁时测量后代的人体测量学。使用双能 X 射线吸收法在出生时和 4 岁时为 SWS 测量体脂肪量；并在出生时和 5 岁时使用空气置换体积描记法为 GUSTO 测量体脂肪量。进行线性回归分析，并调整混杂因素。
结果
在 SWS 中，较高的母体胆碱浓度与新生儿总体脂肪量较高相关{β=0.60 标准差[SD]/5μmol/L 母体胆碱[95%置信区间（CI）0.04-1.16]}和较高的肩胛下皮褶厚度相关[β=0.55mm/5μmol/L（95%CI，0.12-1.00)]在出生时。在 GUSTO 中，较高的母体胆碱浓度与新生儿体重指数-年龄 z 评分较高相关[β=0.31 SD/5μmol/L（0.10-0.51）]和较高的肱三头肌[β=0.38mm/5μmol/L（95%CI，0.11-0.65）]和肩胛下皮褶厚度[β=0.26mm/5μmol/L（95%CI，0.01-0.50）]在出生时。在婴儿后期和幼儿早期，母体胆碱与后代体重指数、皮褶厚度、腰围、体重、长度/身高和肥胖指标的增长之间没有观察到一致的趋势。
结论
我们的研究表明，妊娠期间母体循环胆碱浓度与新生儿 BMI、出生时的皮褶厚度和肥胖度呈正相关，但与婴儿期和幼儿期至 5 岁时的生长和肥胖度无关。
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