T 细胞活化后，IFITM3 迅速发生干扰素非依赖性表达，从而保护细胞免受流感病毒感染。
Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection.
机构信息
Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia.
出版信息
PLoS One. 2019 Jan 16;14(1):e0210132. doi: 10.1371/journal.pone.0210132. eCollection 2019.
Interferon-induced transmembrane protein 3 (IFITM3) is a potent antiviral protein that enhances cellular resistance to a variety of pathogens, including influenza virus. Classically defined as an interferon-stimulated gene, expression of IFITM3 on cells is rapidly up-regulated in response to type I and II interferon. Here we found that IFITM3 is rapidly up-regulated by T cells following their activation and this occurred independently of type I and II interferon and the interferon regulatory factors 3 and 7. Up-regulation of IFITM3 on effector T cells protected these cells from virus infection and imparted a survival advantage at sites of virus infection. Our results show that IFITM3 expression on effector T cells is crucial for these cells to mediate their effector function and highlights an interferon independent pathway for the induction of IFITM3 which, if targeted, could be an effective approach to harness the activity of IFITM3 for infection prevention.
干扰素诱导跨膜蛋白 3（IFITM3）是一种有效的抗病毒蛋白，可增强细胞对多种病原体（包括流感病毒）的抵抗力。IFITM3 经典地被定义为干扰素刺激基因，其在细胞中的表达可迅速被 I 型和 II 型干扰素上调。在这里，我们发现 T 细胞在激活后会迅速上调 IFITM3，而这一过程独立于 I 型和 II 型干扰素以及干扰素调节因子 3 和 7。效应 T 细胞中 IFITM3 的上调可保护这些细胞免受病毒感染，并在病毒感染部位赋予生存优势。我们的结果表明，效应 T 细胞上 IFITM3 的表达对于这些细胞发挥其效应功能至关重要，并强调了一种独立于干扰素的 IFITM3 诱导途径，如果针对该途径进行靶向治疗，可能成为利用 IFITM3 活性预防感染的有效方法。
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