治疗慢性糖尿病伤口的多微生物感染。
Treating Polymicrobial Infections in Chronic Diabetic Wounds.
机构信息
Department of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA.
Department of Biology, Northeastern University, Boston, Massachusetts, USA.
出版信息
Clin Microbiol Rev. 2019 Jan 16;32(2). doi: 10.1128/CMR.00091-18. Print 2019 Apr.
Abstract
This review provides a comprehensive summary of issues associated with treating polyclonal bacterial biofilms in chronic diabetic wounds. We use this as a foundation and discuss the alternatives to conventional antibiotics and the emerging need for suitable drug delivery systems. In recent years, extraordinary advances have been made in the field of nanoparticle synthesis and packaging. However, these systems have not been incorporated into the clinic for treatments other than for cancer or severe genetic diseases. We present a unifying perspective on how the field is evolving and the need for an early amalgamation of engineering principles and a biological understanding of underlying phenomena in order to develop a therapy that is translatable to the clinic in a shorter time.
摘要
这篇综述全面总结了治疗慢性糖尿病创面多克隆细菌生物膜相关问题。我们以此为基础，讨论了替代传统抗生素的方法以及对合适药物输送系统的新需求。近年来，纳米颗粒合成和包装领域取得了非凡的进展。然而，这些系统尚未被应用于癌症或严重遗传疾病以外的治疗。我们提出了一个统一的观点，即该领域正在如何发展，以及需要将工程原理和对潜在现象的生物学理解早期融合，以开发一种更能在短时间内转化为临床应用的疗法。
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