George Goldy C, Buford Adrianna, Hess Kenneth, Piha-Paul Sarina A, Zinner Ralph, Subbiah Vivek, Hinojosa Christina, Cleeland Charles S, Meric-Bernstam Funda, Bernstam Elmer V, Hong David S
Goldy C. George, Adrianna Buford, Kenneth Hess, Sarina A. Piha-Paul, Ralph Zinner, Vivek Subbiah, Christina Hinojosa, Charles S. Cleeland, Funda Meric-Bernstam, and David S. Hong, The University of Texas MD Anderson Cancer Center; and Elmer V. Bernstam, The University of Texas School of Biomedical Informatics, Houston, TX.
JCO Clin Cancer Inform. 2018 Dec;2:1-14. doi: 10.1200/CCI.17.00030.
We examined patterns, correlates, and the impact of cancer-related Internet use among patients with advanced cancer in a phase I clinical trials clinic for molecularly targeted oncologic agents.
An anonymous questionnaire on Internet use for cancer-related purposes that incorporated input from phase I clinical trial oncologists and patients was self-administered by patients age ≥ 18 years in a phase I clinic. Multivariable modeling was used. Data were analyzed for the overall sample and by generation, which was defined by year of birth.
Of 291 patients (52% women, 82% non-Hispanic white, 50% age ≤ 60 years), 62% were cancer-related Internet users (CIUs). Cancer-related Internet use was associated with an income of ≥ $60,000 (odds ratio, 2.42; P = .004). CIUs used the Internet to learn about their cancer (85%), treatment adverse effects (65%), clinical trials (52%), new alternative treatments (42%), and symptom management (41%). CIUs most frequently used the hospital Web site (70%) to learn about clinical trials, followed by ClinicalTrials.gov (42%) and search engines (41%). The emotional impact of Internet-derived cancer information on CIUs varied-56% felt empowered, 34% anxious, 29% relieved, and 17% confused. Cancer-related Internet information made 51% of patients from the Millennial (born after 1990) and Generation X/Y (born 1965 to 1990) CIU populations anxious compared with < 29% of CIUs from older generations (born 1964 and before). Most CIUs desired more online information about new experimental drugs (91%) and US Food and Drug Administration-approved drugs for cancer (72%).
As most phase I patients use the Internet for cancer-related purposes, the Internet overall and hospital Web sites should provide more extensive, pertinent, and helpful information on clinical trials and cancer treatment to phase I patients.
我们在一家针对分子靶向肿瘤药物的I期临床试验诊所，研究了晚期癌症患者使用互联网与癌症相关的模式、关联因素及其影响。
一份关于用于癌症相关目的互联网使用情况的匿名问卷，纳入了I期临床试验肿瘤学家和患者的意见，由年龄≥18岁的患者在I期诊所自行填写。采用多变量建模。对总体样本和按出生年份定义的代际进行数据分析。
在291名患者（52%为女性，82%为非西班牙裔白人，50%年龄≤60岁）中，62%是癌症相关互联网用户（CIU）。癌症相关互联网使用与收入≥6万美元相关（比值比，2.42；P = 0.004）。CIU使用互联网了解他们的癌症（85%）、治疗不良反应（65%）、临床试验（52%）、新的替代治疗（42%）和症状管理（41%）。CIU最常使用医院网站（70%）了解临床试验，其次是ClinicalTrials.gov（42%）和搜索引擎（41%）。互联网获取的癌症信息对CIU的情感影响各不相同——56%感到有力量，34%焦虑，29%宽慰，17%困惑。与出生于1964年及以前的老一辈CIU人群中不到29%相比，癌症相关互联网信息使千禧一代（1990年后出生）和X/Y一代（1965年至1990年出生）CIU人群中的51%感到焦虑。大多数CIU希望获得更多关于新实验药物（91%）和美国食品药品监督管理局批准的癌症药物（72%）的在线信息。
由于大多数I期患者将互联网用于癌症相关目的，互联网总体以及医院网站应向I期患者提供更广泛、相关且有用的关于临床试验和癌症治疗的信息。
