School Health Science, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
Priority Research Centre in Physical Activity and Nutrition, University of Newcastle, Callaghan, NSW 2308, Australia.
Nutrients. 2019 Jan 16;11(1):181. doi: 10.3390/nu11010181.
The aim of this study was to examine the effect of a six-week 2 × 2 design on pain scores, quality of life, and dietary intake in patients attending an Australian tertiary pain clinic. The two intervention components were (1) personalized dietary consultations or waitlist control, and (2) active or placebo dietary supplement (fruit juice). Sixty participants were randomized into one of four groups at baseline (68% female, mean age 49 ± 15 years) with 42 completing the study (70% retention). All groups had statistically significant improvements in three of five pain outcomes. The personalized dietary consultation groups had clinically important improvements in three of five pain outcomes compared to the waitlist control groups. All groups had a statistically significant improvement in six of eight quality-of-life categories post intervention. All groups increased percentage energy from nutrient-dense foods (+5.2 ± 1.4%, < 0.001) with a significant group-by-time effect for percentage energy from total fat ( = 0.024), with the personalized dietary consultations plus placebo fruit juice reporting the largest reduction (-5.7 ± 2.3%). This study indicates that dietitian-delivered dietary intervention can improve pain scores, quality of life, and dietary intake of people experiencing chronic pain. Future research should evaluate efficacy in a full-powered randomized control trial.
本研究旨在考察为期六周的 2×2 设计对澳大利亚一家三级疼痛诊所就诊患者的疼痛评分、生活质量和饮食摄入的影响。两种干预措施包括（1）个性化饮食咨询或候补对照组，以及（2）活性或安慰剂饮食补充剂（果汁）。60 名参与者在基线时随机分为四组（68%为女性，平均年龄 49±15 岁），其中 42 名完成了研究（70%的保留率）。所有组在五项疼痛结果中的三项均有统计学显著改善。与候补对照组相比，个性化饮食咨询组在五项疼痛结果中的三项有临床重要改善。所有组在八项生活质量类别中的六项均有统计学显著改善。所有组的营养密集型食物的能量百分比均有显著增加（+5.2±1.4%，<0.001），总脂肪的能量百分比存在显著的组间时间效应（=0.024），接受个性化饮食咨询和安慰剂果汁的组报告的降幅最大（-5.7±2.3%）。本研究表明，营养师提供的饮食干预可以改善慢性疼痛患者的疼痛评分、生活质量和饮食摄入。未来的研究应在全效随机对照试验中评估疗效。
