Gustave Roussy Cancer Campus Grand Paris, Villejuif, France Cancer Core Europe, France.
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Mol Oncol. 2019 Mar;13(3):521-527. doi: 10.1002/1878-0261.12447. Epub 2019 Feb 2.
Cancer Core Europe is a European legal alliance consisting of seven leading cancer centres - most of them Comprehensive Cancer Centres (CCCs) - with a single portal system to engage in various research projects with partners. Cancer Core Europe was established to create a sustainable, high-level, shared research infrastructure platform hosting research collaborations and task forces (data sharing, clinical trials, genomics, immunotherapy, imaging, education and training, and legal and ethical issues), with a controlled expansion agenda. Translational cancer research covers the cancer research continuum from basic to preclinical to early clinical, late clinical, and outcomes research. Basic-preclinical research serves as the 'engine' for early clinical research by bridging the early translational research gap and is the primary and current focus of the consortium as exemplified by the launching of the Basket of Baskets trial, Europe's largest precision cancer medicine trial. Inspired by the creation of Cancer Core Europe, the prevention community established Cancer Prevention Europe, a consortium of ten cancer prevention centres aimed at supporting the complete prevention research continuum. Presently, Cancer Core Europe and Cancer Prevention Europe are integrating therapeutics and prevention strategies to address in partnership the widening cancer problem. By providing innovative approaches for cancer research, links to healthcare systems, development of quality-assured multidisciplinary cancer care, and assessment of long-term outcomes, the virtual infrastructure will serve as a hub to connect and interact with other centres across Europe and beyond. Together, Cancer Core Europe and Cancer Prevention Europe are prepared to function as a central engine to tackle, in collaboration with various partners, a potential 'mission on cancer' addressing the cancer burden.
欧洲癌症核心是一个由七个领先的癌症中心组成的欧洲法律联盟——其中大多数是综合性癌症中心 (CCCs)——拥有一个单一的门户系统，以与合作伙伴开展各种研究项目。欧洲癌症核心的成立是为了创建一个可持续、高水平、共享的研究基础设施平台，主持研究合作和工作组（数据共享、临床试验、基因组学、免疫疗法、成像、教育和培训以及法律和伦理问题），并制定了控制扩张的议程。转化癌症研究涵盖了从基础到临床前、早期临床、晚期临床和结果研究的癌症研究连续体。基础-临床前研究作为早期临床研究的“引擎”，通过弥合早期转化研究的差距，为早期临床研究提供支持，这是该联盟的主要和当前重点，例如启动了篮子试验，这是欧洲最大的精准癌症医学试验。受欧洲癌症核心成立的启发，预防界成立了欧洲癌症预防组织，这是一个由十个癌症预防中心组成的联盟，旨在支持完整的预防研究连续体。目前，欧洲癌症核心和欧洲癌症预防组织正在整合治疗和预防策略，以合作应对不断扩大的癌症问题。通过为癌症研究提供创新方法、与医疗保健系统的联系、发展有质量保证的多学科癌症护理以及评估长期结果，虚拟基础设施将作为一个枢纽，与欧洲和其他地区的其他中心进行连接和互动。欧洲癌症核心和欧洲癌症预防组织一起准备作为一个中央引擎，与各种合作伙伴合作，共同应对潜在的“癌症使命”，以解决癌症负担问题。
