Lian Feihe, Chi Jun, Meng Qionglin, Li Qingxia, Chen Anying, Wang Zhimin, Dai Liping
Henan University of Chinese Medicine, Zhengzhou, Henan 450046, PR China; Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Zhengzhou, Henan 450046, PR China.
Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Zhengzhou, Henan 450046, PR China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, PR China.
Fitoterapia. 2023 Apr;166:105441. doi: 10.1016/j.fitote.2023.105441. Epub 2023 Feb 1.
Six new cucurbitane-type triterpenes, hemchinins A-F (1-6), together with thirteen known ones (7-19) were isolated from ethyl acetate extraction of Hemsleya chinensis tubers. Compounds 1-2 were a group of cucurbitane triterpenes possessing an infrequent pentacyclic framework. Their structures were established by comprehensive UV, IR, HRMS, 1D/2D NMR, and ECD analyses. Bioassay results showed that most isolated compounds exhibited anti-inflammatory actions, in which compounds 13 and 15 exhibited stronger activities at 6.25 μM, with NO inhibition rates of 49.00 ± 0.05% and 48.40 ± 0.10%, respectively.
从中华雪胆块茎的乙酸乙酯提取物中分离得到6个新的葫芦烷型三萜，即雪胆素A-F（1-6），以及13个已知化合物（7-19）。化合物1-2是一组具有罕见五环骨架的葫芦烷三萜。通过综合紫外光谱、红外光谱、高分辨质谱、一维/二维核磁共振光谱和电子圆二色光谱分析确定了它们的结构。生物活性测试结果表明，大多数分离得到的化合物具有抗炎活性，其中化合物13和15在6.25 μM浓度下表现出较强的活性，一氧化氮抑制率分别为49.00±0.05%和48.40±0.10%。
