• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

单侧外固定架联合载抗生素硫酸钙治疗骨髓炎致胫骨骨缺损的疗效分析：一项回顾性研究。

Management of Osteomyelitis-Induced Massive Tibial Bone Defect by Monolateral External Fixator Combined with Antibiotics-Impregnated Calcium Sulphate: A Retrospective Study.

机构信息

Department of Orthopedics and Traumatology, Guangdong Second Provincial General Hospital, 466 Xingang Road C., Haizhu District, Guangzhou 510317, China.

Department of Orthopedics and Traumatology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China.

出版信息

Biomed Res Int. 2018 Dec 19;2018:9070216. doi: 10.1155/2018/9070216. eCollection 2018.

DOI:10.1155/2018/9070216
PMID:30662918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6313967/
Abstract

AIM

The present study is aimed at evaluating the effect of combined treatment on massive bone defect using radical debridement, antibiotic calcium sulphate, and monolateral external fixator.

METHODS

35 patients with tibial osteomyelitis received radical debridement, and during surgery antibiotics-impregnated calcium sulphate was used for filling the bone defect. Monolateral external fixator was used to manage the bone defect of average 95 (61-185) cm.

RESULTS

Bone union was achieved in 34 patients (97.1%) with no reinfection. One case was presented with reinfection and further debridement was conducted. The average time for the utility of external fixation was 17 (7-32) months, and external fixation index (EFI) was 1.79 mon/cm. The mean follow-up duration after surgery was 33.7 (21-41) months. 19, 13, and 3 patients got excellent, good, and fair bone results, respectively. Meanwhile, functional results were excellent, good, fair, and poor in 13, 15, 6, and 1 patient. The most common complication was pain (100%) and superficial pin-tract infection (22.8%). Delayed maturation was incurred in 2 patients.

CONCLUSION

Our study reveals that radical debridement combined with antibiotics-impregnated calcium sulphate can suppress infection, and distraction osteogenesis using monolateral external fixators plays an effective role in managing osteomyelitis-induced massive tibial bone defect.

摘要

目的

本研究旨在评估采用根治性清创术、抗生素硫酸钙和单侧外固定架联合治疗对大块骨缺损的效果。

方法

35 例胫骨骨髓炎患者接受根治性清创术，术中使用载抗生素硫酸钙填充骨缺损，平均骨缺损 95cm（61-185cm）采用单侧外固定架进行骨缺损管理。

结果

34 例患者（97.1%）获得骨愈合，无再感染。1 例出现再感染，进一步清创。外固定架使用时间平均为 17 个月（7-32 个月），外固定指数（EFI）为 1.79 个月/cm。术后平均随访时间为 33.7 个月（21-41 个月）。19 例、13 例和 3 例患者的骨愈合结果分别为优、良和可。同时，13 例、15 例、6 例和 1 例患者的功能结果分别为优、良、可和差。最常见的并发症是疼痛（100%）和浅表钉道感染（22.8%）。2 例发生延迟愈合。

结论

本研究表明，根治性清创术联合抗生素硫酸钙可抑制感染，单侧外固定架的牵张成骨在治疗骨髓炎引起的大块胫骨骨缺损方面发挥了有效作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/daa566311379/BMRI2018-9070216.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/c12db40537c8/BMRI2018-9070216.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/c1a5cb0c3937/BMRI2018-9070216.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/e38d8920d53a/BMRI2018-9070216.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/bd0e68cd84d8/BMRI2018-9070216.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/daa566311379/BMRI2018-9070216.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/c12db40537c8/BMRI2018-9070216.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/c1a5cb0c3937/BMRI2018-9070216.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/e38d8920d53a/BMRI2018-9070216.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/bd0e68cd84d8/BMRI2018-9070216.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe07/6313967/daa566311379/BMRI2018-9070216.005.jpg

相似文献

1
Management of Osteomyelitis-Induced Massive Tibial Bone Defect by Monolateral External Fixator Combined with Antibiotics-Impregnated Calcium Sulphate: A Retrospective Study.单侧外固定架联合载抗生素硫酸钙治疗骨髓炎致胫骨骨缺损的疗效分析：一项回顾性研究。
Biomed Res Int. 2018 Dec 19;2018:9070216. doi: 10.1155/2018/9070216. eCollection 2018.
2
Reconstruction of massive tibial defect caused by osteomyelitis using induced membrane followed by trifocal bone transport technique: a retrospective study and our experience.采用诱导膜技术联合三焦点骨搬运技术治疗骨髓炎导致的胫骨大段骨缺损：回顾性研究及我们的经验。
BMC Surg. 2021 Dec 15;21(1):419. doi: 10.1186/s12893-021-01421-x.
3
[Trifocal bone transport by using monolateral rail system in treatment of bone defects caused by post-traumatic tibial osteomyelitis].[采用单侧轨道系统进行三焦点骨搬运治疗创伤后胫骨骨髓炎所致骨缺损]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2020 Jul 15;34(7):862-868. doi: 10.7507/1002-1892.201912034.
4
Circular external fixation and cemented PMMA spacers for the treatment of complex tibial fractures and infected nonunions with segmental bone loss.环形外固定及骨水泥聚甲基丙烯酸甲酯间隔物治疗复杂胫骨骨折及伴有节段性骨缺损的感染性骨不连。
J Orthop Surg (Hong Kong). 2017 May-Aug;25(2):2309499017716242. doi: 10.1177/2309499017716242.
5
[Callus Distraction in the Treatment of Post-Traumatic Defects of the Femur and Tibia].[骨痂延长术治疗股骨和胫骨创伤后缺损]
Acta Chir Orthop Traumatol Cech. 2016;83(6):388-392.
6
Reconstruction of segmental bone defects due to chronic osteomyelitis with use of an external fixator and an intramedullary nail.使用外固定器和髓内钉重建慢性骨髓炎所致节段性骨缺损。
J Bone Joint Surg Am. 2006 Oct;88(10):2137-45. doi: 10.2106/JBJS.E.01152.
7
Treatment of tibial large bone defects: A comparative study of bone transport over an intramedullary nail in combination with antibiotic-impregnated calcium sulphate versus bone transport alone with antibiotic-impregnated calcium sulphate.胫骨大骨缺损的治疗：髓内钉联合抗生素浸渍硫酸钙的骨搬运与单纯抗生素浸渍硫酸钙骨搬运的比较研究
Injury. 2023 Apr;54 Suppl 2:S78-S85. doi: 10.1016/j.injury.2022.09.042. Epub 2022 Sep 24.
8
Ilizarov segmental bone transport of infected tibial nonunions requiring extensive debridement with an average distraction length of 9,5 centimetres. Is it safe?伊里扎洛夫节段性骨搬运治疗需要广泛清创的感染性胫骨骨不连，平均牵开长度为 9.5 厘米。它安全吗？
Injury. 2021 Aug;52(8):2425-2433. doi: 10.1016/j.injury.2019.12.025. Epub 2019 Dec 17.
9
Bifocal compression-distraction in the acute treatment of grade III open tibia fractures with bone and soft-tissue loss: a report of 24 cases.双焦点加压-撑开技术在急性治疗伴有骨与软组织缺损的Ⅲ度开放性胫骨骨折中的应用：24例报告
J Orthop Trauma. 2004 Mar;18(3):150-7. doi: 10.1097/00005131-200403000-00005.
10
Bone transport with an external fixator and a locking plate for segmental tibial defects.骨搬运结合外固定架和锁定钢板治疗胫骨节段性骨缺损。
Bone Joint J. 2013 Dec;95-B(12):1667-72. doi: 10.1302/0301-620X.95B12.31507.

引用本文的文献

1
A retrospective study of the anterolateral thigh perforator flap in the treatment of chronic osteomyelitis of the leg with skin defects.股前外侧穿支皮瓣治疗小腿慢性骨髓炎伴皮肤缺损的回顾性研究
JPRAS Open. 2024 Jul 22;41:376-388. doi: 10.1016/j.jpra.2024.07.006. eCollection 2024 Sep.
2
Current application and future perspectives of antimicrobial degradable bone substitutes for chronic osteomyelitis.抗菌可降解骨替代物在慢性骨髓炎中的当前应用及未来展望
Front Bioeng Biotechnol. 2024 Mar 27;12:1375266. doi: 10.3389/fbioe.2024.1375266. eCollection 2024.
3
Non‑contact locking plate: A useful alternative to external fixation in second‑stage treatment of post‑traumatic tibial osteomyelitis.

本文引用的文献

1
The use of a biodegradable antibiotic-loaded calcium sulphate carrier containing tobramycin for the treatment of chronic osteomyelitis: a series of 195 cases.使用含妥布霉素的可生物降解载抗生素硫酸钙载体治疗慢性骨髓炎：195例系列病例。
Bone Joint J. 2014 Jun;96-B(6):829-36. doi: 10.1302/0301-620X.96B6.32756.
2
C-reactive protein kinetics after major surgery.大手术后C反应蛋白的动力学变化
Anesth Analg. 2014 Sep;119(3):624-629. doi: 10.1213/ANE.0000000000000263.
3
Management of nonunion of lower-extremity long bones using mono-lateral external fixator--report of 37 cases.
非接触锁定钢板：创伤后胫骨骨髓炎二期治疗中一种有用的外固定替代方法。
Exp Ther Med. 2024 Mar 26;27(5):230. doi: 10.3892/etm.2024.12518. eCollection 2024 May.
4
The efficacy of antibiotic-impregnated calcium sulfate (AICS) in the treatment of infected non-union and fracture-related infection: a systematic review.抗生素浸渍硫酸钙（AICS）治疗感染性骨不连及骨折相关感染的疗效：一项系统评价
J Bone Jt Infect. 2023 Mar 22;8(2):91-97. doi: 10.5194/jbji-8-91-2023. eCollection 2023.
5
A scoping review of the outcome reporting following surgery for chronic osteomyelitis of the lower limb.下肢慢性骨髓炎手术后结局报告的范围综述。
Bone Jt Open. 2023 Mar 7;4(3):146-157. doi: 10.1302/2633-1462.43.BJO-2022-0109.R1.
6
Antibacterial and Anti-Biofilm Properties of Diopside Powder Loaded with Lysostaphin.负载溶葡萄球菌酶的透辉石粉末的抗菌和抗生物膜特性
Pathogens. 2023 Jan 23;12(2):177. doi: 10.3390/pathogens12020177.
7
New bone formation using antibiotic-loaded calcium sulfate beads in bone transports for the treatment of long-bone osteomyelitis.应用载抗生素硫酸钙珠的新骨形成术在骨搬运治疗长骨骨髓炎中的应用。
Eur J Orthop Surg Traumatol. 2023 Aug;33(6):2489-2496. doi: 10.1007/s00590-022-03461-2. Epub 2022 Dec 22.
8
Acute hematogenous osteomyelitis in children: Management of pandiaphysitis with extensive bone destruction: A case series of thirteen child.儿童急性血源性骨髓炎：广泛骨质破坏的全骨干炎的治疗：13例儿童病例系列
Ann Med Surg (Lond). 2022 Sep 8;82:104578. doi: 10.1016/j.amsu.2022.104578. eCollection 2022 Oct.
9
[Carbon monoxide intoxication-New aspects and current guideline-based recommendations].[一氧化碳中毒——新观点及基于当前指南的建议]
Anaesthesiologie. 2022 Oct;71(10):801-810. doi: 10.1007/s00101-022-01149-0. Epub 2022 Jun 23.
10
Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review and meta-analysis.载抗生素硫酸钙在慢性骨髓炎临床治疗中的应用：系统评价和荟萃分析。
J Orthop Surg Res. 2022 Feb 19;17(1):104. doi: 10.1186/s13018-022-02980-2.
单侧外固定架治疗下肢长骨骨不连——附37例报告
Injury. 2014 Mar;45(3):560-7. doi: 10.1016/j.injury.2013.11.019. Epub 2013 Nov 27.
4
Bone transport with an external fixator and a locking plate for segmental tibial defects.骨搬运结合外固定架和锁定钢板治疗胫骨节段性骨缺损。
Bone Joint J. 2013 Dec;95-B(12):1667-72. doi: 10.1302/0301-620X.95B12.31507.
5
The performance of serum inflammatory markers for the diagnosis and follow-up of patients with osteomyelitis.血清炎症标志物在骨髓炎患者诊断及随访中的表现。
Int J Low Extrem Wounds. 2013 Jun;12(2):94-9. doi: 10.1177/1534734613486152. Epub 2013 May 9.
6
2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections.2012 年美国传染病学会临床实践指南：糖尿病足感染的诊断与治疗。
Clin Infect Dis. 2012 Jun;54(12):e132-73. doi: 10.1093/cid/cis346.
7
Rigidity of unilateral external fixators--a biomechanical study.单侧外固定架的刚性 - 一项生物力学研究。
Injury. 2011 Dec;42(12):1449-54. doi: 10.1016/j.injury.2011.05.024. Epub 2011 Jun 23.
8
The treatment of gustilo grade IIIB tibia fractures with application of antibiotic spacer, flap, and sequential distraction osteogenesis.应用抗生素骨水泥间隔物、皮瓣及序贯性牵张成骨治疗 Gustilo ⅢB 型胫骨骨折
Ann Plast Surg. 2010 May;64(5):541-52. doi: 10.1097/SAP.0b013e3181cf9fb5.
9
Current techniques to detect foot infection in the diabetic patient.检测糖尿病患者足部感染的当前技术。
Int J Low Extrem Wounds. 2010 Mar;9(1):24-30. doi: 10.1177/1534734610363004.
10
Calcium sulfates: what is the evidence?硫酸钙：有何证据？
J Orthop Trauma. 2010 Mar;24 Suppl 1:S46-51. doi: 10.1097/BOT.0b013e3181cec48e.