Kamarlı Altun Hülya, Akal Yıldız Emine, Akın Mete
Department of Nutrition and Dietetics, Akdeniz University School of Health Sciences, Antalya, Turkey.
Department of Nutrition and Dietetics, Eastern Mediterranean University School of Health Sciences, Famagusta, North Cyprus.
Turk J Gastroenterol. 2019 Apr;30(4):313-320. doi: 10.5152/tjg.2019.18356.
BACKGROUND/AIMS: Recently, there has been an increasing interest in the effects of probiotics and prebiotics on ulcerative colitis (UC). In the present study, we aimed to evaluate the effect of synbiotic therapy on the clinical and endoscopic activities of the disease in patients with mild-to-moderately active UC.
Overall, 40 patients with mild-to-moderate UC activity were included in the study and were randomized to the synbiotic and control groups. Synbiotic therapy was administered in the synbiotic group and placebo was administered in the control group for 8 weeks. Both groups were evaluated and compared in terms of the acute phase reactants and clinical and endoscopic activities of the disease at the beginning and at the end of the 8-week therapy.
At the end of the study duration, the decrease in the serum C-reactive protein (CRP) and sedimentation values in the synbiotic group was statistically significant (p=0.003). In both groups, a statistically significant improvement was observed in the clinical and endoscopic activity levels at the end of the treatment (symbiotic: p=0.001 and p=0.002, respectively; control: p=0.005 and p=0.001, respectively). When the groups were compared with each other, improvement in the clinical activity was significantly higher in the synbiotic group (p<0.05).
The use of synbiotic therapy in patients with UC has a significant effect on the improvement in clinical activity. Moreover, although it appears to positively affect the acute phase reactants and endoscopic activity levels, the difference was not significant when compared with the patients who did not receive synbiotic therapy.
背景/目的：近年来，益生菌和益生元对溃疡性结肠炎（UC）的影响日益受到关注。在本研究中，我们旨在评估合生元疗法对轻至中度活动性UC患者疾病的临床和内镜活动的影响。
本研究共纳入40例轻至中度UC活动患者，并随机分为合生元组和对照组。合生元组给予合生元治疗，对照组给予安慰剂，疗程8周。在8周治疗开始和结束时，对两组患者的急性期反应物、疾病的临床和内镜活动进行评估和比较。
研究结束时，合生元组血清C反应蛋白（CRP）和血沉值下降具有统计学意义（p=0.003）。两组治疗结束时临床和内镜活动水平均有统计学意义的改善（合生元组：分别为p=0.001和p=0.002；对照组：分别为p=0.005和p=0.001）。两组比较，合生元组临床活动改善更显著（p<0.05）。
UC患者使用合生元疗法对临床活动改善有显著效果。此外，虽然它似乎对急性期反应物和内镜活动水平有积极影响，但与未接受合生元治疗的患者相比，差异不显著。
