Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Department of Health and Human Performance, University of Houston, Texas, USA.
Sci Rep. 2019 Jul 10;9(1):9989. doi: 10.1038/s41598-019-46429-9.
C-peptide, insulin, leptin, and other metabolic hormones are assumed to play roles in breast cancer development; though, results are inconsistent. In this prospective case-control study nested within the Mano a Mano Cohort Study, we assessed the risk of breast cancer with regard to plasma levels of c-peptide, gastric inhibitory polypeptide, insulin, leptin, monocyte chemoattractant protein-1, pancreatic polypeptide, and peptide YY. Among women followed for a median of 8.5 years, 109 breast cancer cases were identified and frequency-matched to 327 controls at a ratio of 1:3. Overall, only c-peptide was observed significantly associated with breast cancer risk. High c-peptide levels (≥ the median level of controls) were significantly associated with increased breast cancer risk (odds ratio [OR] = 1.39, 95% confidence interval [CI]: 1.01, 2.44). In an analysis of participants stratified by age, the significant association between c-peptide levels and breast cancer risk was evident in only women age ≥51 years (OR = 1.53, 95% CI: 1.02, 3.27). Among women age <51 years, high leptin levels were significantly associated with decreased breast cancer risk (OR = 0.49, 95% CI: 0.24, 0.82). Our findings suggest that selected metabolic hormones are associated with breast cancer development in Mexican American women.
C 肽、胰岛素、瘦素和其他代谢激素被认为在乳腺癌的发展中发挥作用；然而，结果并不一致。在这项前瞻性病例对照研究中，我们评估了 C 肽、胃抑制多肽、胰岛素、瘦素、单核细胞趋化蛋白-1、胰多肽和肽 YY 等血浆水平与乳腺癌风险之间的关系。在中位随访 8.5 年的女性中，确定了 109 例乳腺癌病例，并以 1:3 的比例与 327 例对照进行了频率匹配。总的来说，只有 C 肽与乳腺癌风险呈显著相关。高水平的 C 肽（≥对照的中位数水平）与乳腺癌风险增加显著相关（比值比 [OR] = 1.39，95%置信区间 [CI]：1.01，2.44）。在按年龄分层的参与者分析中，仅在年龄≥51 岁的女性中，C 肽水平与乳腺癌风险之间的显著相关性是明显的（OR = 1.53，95%CI：1.02，3.27）。在年龄<51 岁的女性中，高水平的瘦素与乳腺癌风险降低显著相关（OR = 0.49，95%CI：0.24，0.82）。我们的研究结果表明，一些代谢激素与墨西哥裔美国女性乳腺癌的发展有关。
