Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in Users.

Obesity is treatment-resistant, and is linked with a number of serious, chronic diseases. Adult obesity rates in the United States have tripled since the early 1960s. Recent reviews show that an increased ratio of omega-6 to omega-3 fatty acids contributes to obesity rates by increasing levels of the endocannabinoid signals AEA and 2-AG, overstimulating CBR and leading to increased caloric intake, reduced metabolic rates, and weight gain. , or THC, also stimulates CBR and increases caloric intake during acute exposures. To establish the relationship between use and body mass index, and to provide a theoretical explanation for this relationship. The present meta-analysis reveals significantly reduced body mass index and rates of obesity in users, in conjunction with increased caloric intake. We provide for the first time a causative explanation for this paradox, in which rapid and long-lasting downregulation of CBR following acute consumption reduces energy storage and increases metabolic rates, thus reversing the impact on body mass index of elevated dietary omega-6/omega-3 ratios.