Department of Kinesiology and Applied Physiology, University of Delaware , Newark, Delaware.
Exercise Science and Physical Education Department, Montclair State University , Montclair, New Jersey.
J Neurophysiol. 2019 Mar 1;121(3):1011-1017. doi: 10.1152/jn.00471.2018. Epub 2019 Jan 23.
A positive family history of hypertension (+FH) is a risk factor for the future development of hypertension. Hypertension is associated with reductions in baroreflex sensitivity (BRS). Therefore, we hypothesized that young women with a +FH [ n = 12, 22 ± 1 yr, body mass index (BMI) 21 ± 1 kg/m, mean arterial pressure (MAP) 79 ± 1 mmHg] would have lower BRS compared with young women without a family history of hypertension (-FH) ( n = 13, 22 ± 1 yr, BMI 21 ± 1 kg/m, MAP 77 ± 2 mmHg, all P > 0.05 between groups). Continuous measurements of muscle sympathetic nerve activity, blood pressure, and electrocardiogram derived R-R interval were recorded at rest and during a Valsalva maneuver. Both cardiovagal BRS and vascular sympathetic BRS were assessed. Resting cardiovagal BRS was reduced in the +FH women (all sequences: -FH 32.3 ± 3.7 vs. +FH 20.2 ± 2.9 ms/mmHg, P = 0.02). Cardiovagal BRS during phase IV (-FH 16.5 ± 2.7 vs. +FH 7.6 ± 1.3 ms/mmHg, P < 0.01) but not phase II (-FH 5.5 ± 0.9 vs. +FH 5.0 ± 0.8 ms/mmHg, P = 0.67) of the Valsalva maneuver was also lower in the +FH women. Vascular sympathetic BRS at rest (-FH -2.38 ± 0.7 vs. +FH -2.33 ± 0.3 bursts· min·mmHg, P = 0.58) and during the Valsalva (-FH -0.74 ± 0.23 vs. +FH -0.66 ± 0.18 bursts·15 s·mmHg, P = 0.79) were not different between groups. These data suggest that healthy young women with a positive family history of hypertension have reduced cardiovagal BRS. This may be one mechanism contributing to the increased incidence of hypertension in this population later in life. NEW & NOTEWORTHY Having a family history of hypertension increases the risk of developing future hypertension. Reductions in baroreflex function have been demonstrated in hypertension and are an important marker for future cardiovascular disease. We show that young women with a family history of hypertension have lower cardiovagal baroreflex sensitivity. This alteration in autonomic function may be one mechanism contributing to the future incidence of hypertension in this patient population.
有高血压家族史（+FH）是未来发生高血压的一个危险因素。高血压与压力反射敏感性（BRS）降低有关。因此，我们假设与没有高血压家族史的年轻女性（-FH）相比，有高血压家族史的年轻女性（+FH）的 BRS 更低（+FH，n=12，22±1 岁，体重指数（BMI）21±1kg/m，平均动脉压（MAP）79±1mmHg；-FH，n=13，22±1 岁，BMI 21±1kg/m，MAP 77±2mmHg，两组间所有 P>0.05）。在休息和瓦尔萨尔瓦动作期间，连续记录肌肉交感神经活动、血压和心电图衍生的 R-R 间期。评估了心脏迷走神经 BRS 和血管交感神经 BRS。+FH 女性的静息心脏迷走神经 BRS 降低（所有序列：-FH 32.3±3.7 对 +FH 20.2±2.9ms/mmHg，P=0.02）。+FH 女性在瓦尔萨尔瓦动作的第四期（-FH 16.5±2.7 对 +FH 7.6±1.3ms/mmHg，P<0.01）而不是第二期（-FH 5.5±0.9 对 +FH 5.0±0.8ms/mmHg，P=0.67）的心脏迷走神经 BRS 也较低。在休息时（-FH-2.38±0.7 对 +FH-2.33±0.3 脉冲·min·mmHg，P=0.58）和在瓦尔萨尔瓦动作期间（-FH-0.74±0.23 对 +FH-0.66±0.18 脉冲·15s·mmHg，P=0.79），两组之间的血管交感神经 BRS 没有差异。这些数据表明，有高血压阳性家族史的健康年轻女性心脏迷走神经 BRS 降低。这可能是导致该人群未来生活中高血压发病率增加的一个机制。
新内容和值得注意的内容：
有高血压家族史会增加未来发生高血压的风险。压力反射功能的降低已在高血压中得到证实，是未来心血管疾病的一个重要标志物。我们显示，有高血压家族史的年轻女性心脏迷走神经压力反射敏感性较低。这种自主神经功能的改变可能是导致该患者人群未来高血压发病率的一个机制。
