Mauri Emanuele, Negri Anna, Rebellato Erica, Masi Maurizio, Perale Giuseppe, Rossi Filippo
Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, via Mancinelli 7, 20131 Milan, Italy.
Biomaterials Laboratory, Institute for Mechanical Engineering and Materials Technology, SUPSI-University of Applied Sciences and Arts of Southern Switzerland, via Cantonale 2C, Galleria 2, 6928 Manno, Switzerland.
Gels. 2018 Sep 4;4(3):74. doi: 10.3390/gels4030074.
Biodegradable poly(ethylene glycol)-block-poly(-lactic acid) (PEG--PLA) nanoparticles (NPs) were prepared by nanoprecipitation with controlled dimension and with different electric charges, as monitored by dynamic light scattering (DLS). Then NPs were loaded within hydrogels (HG) developed for biomedical applications in the central nervous system, with different pore sizes (30 and 90 nm). The characteristics of the resulting composite hydrogel-NPs system were firstly studied in terms of ability to control the release of small steric hindrance drug mimetic. Then, diffusion-controlled release of different charged NPs from different entangled hydrogels was studied in vitro and correlated with NPs electric charges and hydrogel mean mesh size. These studies showed different trends, that depend on NPs superficial charge and HG mesh size. Release experiments and diffusion studies, then rationalized by mathematical modeling, allowed us to build different drug delivery devices that can satisfy different medical needs.
通过纳米沉淀法制备了尺寸可控且带有不同电荷的可生物降解聚（乙二醇）-嵌段-聚（-乳酸）（PEG-b-PLA）纳米颗粒（NPs），通过动态光散射（DLS）进行监测。然后将纳米颗粒负载到为中枢神经系统生物医学应用而开发的具有不同孔径（30和90纳米）的水凝胶（HG）中。首先从控制小位阻药物模拟物释放的能力方面研究了所得复合水凝胶-NP系统的特性。然后，在体外研究了不同带电纳米颗粒从不同缠结水凝胶中的扩散控制释放，并将其与纳米颗粒电荷和水凝胶平均网孔尺寸相关联。这些研究显示出不同的趋势，这取决于纳米颗粒的表面电荷和水凝胶网孔尺寸。释放实验和扩散研究，然后通过数学建模进行合理化，使我们能够构建不同的药物递送装置，以满足不同的医疗需求。
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