Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Molecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, European Institute of Oncology, IRCCS, Milan, Italy.
Curr Opin Oncol. 2019 Mar;31(2):65-71. doi: 10.1097/CCO.0000000000000507.
In spite of the established scientific evidence on the association of sunbed use with melanoma risk, some have recently expressed scepticism about the carcinogenicity of indoor tanning. This may have raised confusion among both physicians and patients. The purpose of this review is to make the point about the real impact of sunbed use on melanoma risk in light of the most recently published evidence.
Seven themes were covered: recent studies on age at first sunbed exposure and melanoma risk; sunbed use and melanoma at different body sites; sunbed use and development of additional primary melanomas; new studies on proportion of melanomas attributable to sunbed use; sunbed use and melanoma risk factors; economic burden of sunbed use; and recent debate over whether indoor tanning contributes to melanoma.
We were able to apply all epidemiological criteria for causality to the relationship between sunbed use and melanoma. Together with the new evidence on the strength, dose response, and temporality of the association of sunbeds with melanoma, this will hopefully close the debate over whether indoor tanning contributes to melanoma.
尽管已有科学证据证实日光浴床的使用与黑色素瘤风险之间存在关联,但最近有人对室内晒黑的致癌性表示怀疑。这可能导致医生和患者感到困惑。本文旨在根据最新发表的证据,阐明日光浴床使用对黑色素瘤风险的实际影响。
涵盖了七个主题:日光浴床使用与首次暴露年龄和黑色素瘤风险的最新研究;日光浴床使用与不同身体部位黑色素瘤的关系;日光浴床使用与新发原发性黑色素瘤的关系;日光浴床使用与黑色素瘤归因比例的新研究;日光浴床使用与黑色素瘤风险因素的关系;日光浴床使用的经济负担;以及最近关于室内晒黑是否会导致黑色素瘤的争论。
我们能够将因果关系的所有流行病学标准应用于日光浴床使用与黑色素瘤之间的关系。再加上有关日光浴床与黑色素瘤关联的强度、剂量反应和时间性的新证据,这有望结束关于室内晒黑是否会导致黑色素瘤的争论。