Branisteanu Daciana-Elena, Feodor Toni, Baila Sorin, Mitea Iuliana-Alma, Vittos Oana
Department of Dermatology, University of Medicine and Pharmacy 'Gr. T. Popa', 700115 Iasi, Romania.
Medical Center for Diagnosis, Ambulatory Treatment and Medical Prevention, Surgery Clinic 'Sf. Nicolae', 011796 Bucharest, Romania.
Exp Ther Med. 2019 Feb;17(2):1091-1096. doi: 10.3892/etm.2018.7054. Epub 2018 Dec 5.
Chronic venous disease (CVD) affects millions of people and negatively impacting the patient's quality of life (QoL) and most of the patients are diagnosed with CVD in advanced stages. The impact of newly diagnosed CVD on QoL has not been evaluated by other studies in Romania. The aim of this study was to assess the QoL for adult patients newly diagnosed with CVD addressing to the General Practitioner's (GP) office in Romania between June to August 2016. Patients included in the study were adult, signing the inform consent form, newly diagnosed with CVD or patients diagnosed with CVD, without CVD treatment the past 6 months. Data on demographic distribution, risk factors, clinical profiles, CVD symptomatology, QoL parameters, as well as pharmacological management practice were collected. The study included 1,893 patients (79.08% females) with 50.4% of patients in the age group 51-70 years. The most frequent CVD symptoms reported, were heavy leg sensation (85.74%), swelling of the feet (77.28%) and pain (73.11%). The most frequent CVD signs were telangiectasia and reticular veins (79.19%), varicose veins (65.77%) and edema (53.35%). The clinical, aetiological, anatomical and pathophysiological (CEAP) classification placed most of the patients in C3 class (31.85%), followed by C2 class (28.00%), C1 class (21.02%) and C4a (8.87%). Most of the patients reported 'low' or 'moderate' intensity of the CVD symptoms. QoL was affected for most of the patients at 'a mild' or 'moderate' degree, being noticed as a significant negative impact on physical, psychological, and social functioning components of QoL, correlated with CEAP class (P<0.001). Data regarding correlation of CEAP class, CVD symptoms and impact on QoL identified a significant correlation between all analyzed components (P<0.001). Study results prove that CVD diagnosis was established with relative delay and CVD is negatively affecting patients' QoL. Additional research will be needed to identify the long-term impact of CVD on QoL of the affected patients and their families.
慢性静脉疾病（CVD）影响着数百万人，对患者的生活质量（QoL）产生负面影响，并且大多数患者在疾病晚期才被诊断出患有CVD。罗马尼亚的其他研究尚未评估新诊断出的CVD对生活质量的影响。本研究的目的是评估2016年6月至8月期间前往罗马尼亚全科医生（GP）办公室就诊的新诊断为CVD的成年患者的生活质量。纳入研究的患者为成年人，签署了知情同意书，新诊断为CVD或在过去6个月内未接受CVD治疗的已确诊CVD患者。收集了有关人口分布、危险因素、临床特征、CVD症状、生活质量参数以及药物治疗实践的数据。该研究纳入了1893名患者（79.08%为女性），其中51 - 70岁年龄组的患者占50.4%。报告的最常见CVD症状为腿部沉重感（85.74%）、足部肿胀（77.28%）和疼痛（73.11%）。最常见的CVD体征为毛细血管扩张和网状静脉（79.19%）、静脉曲张（65.77%）和水肿（53.35%）。临床、病因、解剖和病理生理（CEAP）分类将大多数患者归为C3级（31.85%），其次是C2级（28.00%）、C1级（21.02%）和C4a级（8.87%）。大多数患者报告CVD症状的强度为“低”或“中度”。大多数患者的生活质量受到“轻度”或“中度”影响，被认为对生活质量的身体、心理和社会功能组成部分有显著负面影响，与CEAP分级相关（P<0.001）。关于CEAP分级、CVD症状与生活质量影响之间相关性的数据表明，所有分析的组成部分之间存在显著相关性（P<0.001）。研究结果证明，CVD的诊断确立相对延迟，且CVD对患者的生活质量有负面影响。需要进一步的研究来确定CVD对受影响患者及其家庭生活质量的长期影响。
