Cheville N F, Tappe J, Ackermann M, Jensen A
National Animal Disease Center, US Department of Agriculture, Ames, IA.
Vet Pathol. 1988 Sep;25(5):369-75. doi: 10.1177/030098588802500506.
Multiple outbreaks of acute severe fibrinopurulent lesions of the eyelids occurred in chickens and turkeys. Lesions began as tiny foci of epidermal necrosis and ulceration and spread to involve the entire eyelid. Scabs overlying the epidermis contained large gram-positive cocci; lesser numbers of small cocci and gram-negative bacilli were in more superficial areas. Staphylococcus hyicus was isolated from birds in all stages of the disease. Escherichia coli and Streptococcus sp. were isolated only during severe stages; no anaerobic bacterial pathogens were isolated. Vasculitis and perivascular lymphocytic infiltrates in deep layers of the dermis suggested that a staphylococcal toxin may have been involved. The disease was not reproduced by scarifying S. hyicus onto the eyelids or by intravenous inoculation of retrovirus-infected chickens.
鸡和火鸡中多次爆发眼睑急性严重纤维蛋白脓性病变。病变始于表皮坏死和溃疡的微小病灶，随后蔓延至整个眼睑。覆盖表皮的痂皮中含有大量革兰氏阳性球菌；在较浅区域有少量小球菌和革兰氏阴性杆菌。从疾病各阶段的禽类中分离出了猪葡萄球菌。仅在严重阶段分离出大肠杆菌和链球菌属；未分离出厌氧细菌病原体。真皮深层的血管炎和血管周围淋巴细胞浸润表明可能涉及葡萄球菌毒素。通过在眼睑上划破猪葡萄球菌或静脉接种感染逆转录病毒的鸡，均未再现该疾病。
