a Adult and Child Consortium for Outcomes Research and Dissemination Science, University of Colorado , Aurora, CO , USA.
b Department of Biostatistics and Informatics, University of Colorado , Aurora , CO , USA.
Hum Vaccin Immunother. 2019;15(7-8):1577-1584. doi: 10.1080/21645515.2018.1559685. Epub 2019 Feb 20.
Human papillomavirus (HPV) causes a number of cancers that disproportionally affect Latinos yet there is a paucity of research on interventions to increase HPV vaccination among this population. We sought to evaluate the efficacy of a web-based, individually customizable intervention, called CHICOs (ombatting PV nfection and ancer tailored intervention) for its impact on HPV vaccine utilization. We conducted a three-armed, randomized, controlled trial in the waiting rooms of five family medicine practices from June 2014-February 2016 where CHICOS was compared to an iPad-based version of the Vaccine Information Sheet from the Centers for Disease Control and Prevention (untailored intervention), and usual care. Pair-wise comparisons between study arms of 6 different measures of HPV vaccine uptake were assessed, with analyses stratified by adolescents versus young adults. Of the 1,294 participants enrolled in the study, 1,013 individuals could be assessed for vaccination. Across study arms, 265 adolescents, but only 18 young adults, received an HPV vaccine dose during the study period. In both intention-to-treat and per-protocol analyses there were essentially no differences between the CHICOS and untailored arms in any vaccination measure, or between the untailored or CHICOS arms and usual care. Our study suggests that a tailored educational intervention may not be effective for increasing HPV vaccine uptake among Latino adolescents or young adults. However, the higher than expected baseline levels of positive vaccination attitudes of study participants could have diminished the statistical power of the study. Trial Registration Number: ClinicalTrials.gov (NCT02145156).
人乳头瘤病毒（HPV）可引发多种癌症，对拉丁裔人群的影响尤为显著，但针对该人群提高 HPV 疫苗接种率的干预措施研究却很少。我们旨在评估一种名为 CHICOs（对抗 HPV 感染和癌症的个性化干预措施）的基于网络的、可个性化定制的干预措施的效果，该干预措施旨在评估其对 HPV 疫苗接种率的影响。我们在 2014 年 6 月至 2016 年 2 月期间在五家家庭医疗诊所的候诊室进行了一项三臂、随机、对照试验，将 CHICOS 与疾病控制与预防中心（CDC）的基于 iPad 的疫苗信息表（未定制的干预措施）和常规护理进行了比较。对 6 项不同 HPV 疫苗接种率指标的研究臂进行了两两比较，并按青少年与年轻成年人进行了分层分析。在该研究中，共有 1294 名参与者，其中 1013 人可以评估接种情况。在研究期间，在所有研究臂中，265 名青少年但只有 18 名年轻成年人接受了 HPV 疫苗接种。在意向治疗和符合方案分析中，CHICOS 与未定制组在任何接种指标上，或在未定制组和 CHICOS 组与常规护理组之间，均基本没有差异。我们的研究表明，针对拉丁裔青少年或年轻成年人的个性化教育干预措施可能无法有效提高 HPV 疫苗接种率。然而，研究参与者的疫苗接种态度的基线水平高于预期，这可能降低了该研究的统计效力。试验注册号：ClinicalTrials.gov（NCT02145156）。
