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CD8+ T cell supernatants of HIV type 1-infected individuals have opposite effects on long terminal repeat-mediated transcription in T cells and monocytes.1型人类免疫缺陷病毒感染个体的CD8 + T细胞上清液对T细胞和单核细胞中长末端重复序列介导的转录具有相反的作用。
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本文引用的文献

1
Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy.表达组织因子的炎症单核细胞驱动 SIV 和 HIV 凝血障碍。
Sci Transl Med. 2017 Aug 30;9(405). doi: 10.1126/scitranslmed.aam5441.
2
Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection.单核细胞和内皮细胞黏附分子表达改变与人类免疫缺陷病毒感染中的血管炎症相关。
Open Forum Infect Dis. 2016 Oct 15;3(4):ofw224. doi: 10.1093/ofid/ofw224. eCollection 2016 Oct.
3
Inflammatory Function of CX3CR1+ CD8+ T Cells in Treated HIV Infection Is Modulated by Platelet Interactions.血小板相互作用调节经治疗的HIV感染中CX3CR1+ CD8+ T细胞的炎症功能。
J Infect Dis. 2016 Dec 15;214(12):1808-1816. doi: 10.1093/infdis/jiw463. Epub 2016 Oct 4.
4
Macrophages in Vascular Inflammation: Origins and Functions.血管炎症中的巨噬细胞：起源与功能
Curr Atheroscler Rep. 2016 Jun;18(6):34. doi: 10.1007/s11883-016-0585-2.
5
Role of CX3CL1 in Diseases.CX3CL1在疾病中的作用。
Arch Immunol Ther Exp (Warsz). 2016 Oct;64(5):371-83. doi: 10.1007/s00005-016-0395-9. Epub 2016 Apr 20.
6
Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection.犯罪伙伴：巨细胞病毒在HIV感染期间免疫失调及临床结局中的作用
Curr HIV/AIDS Rep. 2016 Feb;13(1):10-9. doi: 10.1007/s11904-016-0297-9.
7
SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like Factor 2 and Endothelial Dysfunction.猴免疫缺陷病毒/猿猴-人免疫缺陷病毒感染引发血管炎症、Krüppel样因子2表达降低及内皮功能障碍。
J Infect Dis. 2016 May 1;213(9):1419-27. doi: 10.1093/infdis/jiv749. Epub 2015 Dec 15.
8
Altered Maturation Status and Possible Immune Exhaustion of CD8 T Lymphocytes in the Peripheral Blood of Patients Presenting With Acute Coronary Syndromes.急性冠状动脉综合征患者外周血中CD8 T淋巴细胞成熟状态改变及可能的免疫耗竭
Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):389-97. doi: 10.1161/ATVBAHA.115.306112. Epub 2015 Dec 10.
9
CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection.CD8 T细胞扩增及炎症反应与接受抗逆转录病毒治疗的HIV感染者中的巨细胞病毒合并感染相关
Clin Infect Dis. 2016 Feb 1;62(3):392-6. doi: 10.1093/cid/civ840. Epub 2015 Sep 23.
10
Activated platelet-T-cell conjugates in peripheral blood of patients with HIV infection: coupling coagulation/inflammation and T cells.HIV感染患者外周血中活化的血小板-T细胞结合物：凝血/炎症与T细胞的关联
AIDS. 2015 Jul 17;29(11):1297-308. doi: 10.1097/QAD.0000000000000701.

CD8+ T 细胞衍生的肿瘤坏死因子可诱导单核细胞表达组织因子。

CD8+ T-Cell-Derived Tumor Necrosis Factor Can Induce Tissue Factor Expression on Monocytes.

机构信息

Center for AIDS Research, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland.

Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland.

出版信息

J Infect Dis. 2019 Jun 5;220(1):73-77. doi: 10.1093/infdis/jiz051.

DOI:10.1093/infdis/jiz051
PMID:30698729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6548895/
Abstract

Circulating CD8+ T cells and monocytes are activated during human immunodeficiency virus (HIV) infection and colocalize in the aortas of simian immunodeficiency virus-infected nonhuman primates. We hypothesized that CD8+ T cells could exert a proatherosclerotic effect via paracrine actions on monocytes. We found that T-cell receptor-stimulated CD8+ T cells induce monocytes to express tissue factor, a potent activator of coagulation. Tumor necrosis factor was both necessary and sufficient for this effect.

摘要

循环 CD8+T 细胞和单核细胞在人类免疫缺陷病毒 (HIV) 感染期间被激活，并在感染猴免疫缺陷病毒的非人类灵长类动物的主动脉中聚集。我们假设 CD8+T 细胞可以通过旁分泌作用对单核细胞发挥促动脉粥样硬化作用。我们发现，T 细胞受体刺激的 CD8+T 细胞诱导单核细胞表达组织因子，组织因子是凝血的有效激活剂。肿瘤坏死因子是这种作用所必需的，也是充分的。