SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Private Bag X1314, Alice, Eastern Cape Province, 5700, South Africa.
Applied and Environmental Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X1314, Alice, Eastern Cape Province, 5700, South Africa.
BMC Complement Altern Med. 2019 Jan 30;19(1):34. doi: 10.1186/s12906-019-2445-4.
Streptococcus agalactiae also known as Group B Streptococcus (GBS) is a major cause of disease in pregnant women and new born babies where it causes early and late onset disease characterised by sepsis, pneumonia and meningitis. Ten to 37 % of pregnant women in the world are colonised with GBS while intrapartum antibiotic prophylaxis has led to significant reduction in early onset disease. The increase in drug resistant microorganisms has become a major threat. Development of vaccines is still in progress so there is need for new and safer alternatives to treatment.
Benzyl penicillin, Ampicillin, Cefotaxime, Ceftriaxone, Levofloxacin, Erythromycin, Clindamycin, Linezolid, Vancomycin, Tetracycline and Cotrimoxazole, Olea europaea leaf extracts and essential oil were tested against GBS isolates from South Africa and Namibia.
The isolates showed 100% sensitivity to benzyl penicillin, ampicillin, ceftriaxone, levofloxacin, linezolid, vancomycin, O. europaea leaf extracts and essential oils. Only one isolate (0.6%) was resistant to cefotaxime and 23.4 and 10.4% were resistant to clindamycin and erythromycin respectively.
GBS isolates showed sensitivity to O. europaea extracts at low minimum inhibitory concentrations. Β lactams are still the drugs of choice for treatment of GBS disease but O. europaea extracts potent as an alternative source of antimicrobials.
无乳链球菌又称 B 组链球菌（GBS），是导致孕妇和新生儿疾病的主要原因，可引起早发性和晚发性疾病，其特征为败血症、肺炎和脑膜炎。全世界有 10%至 37%的孕妇定植有 GBS，而产时抗生素预防已显著降低了早发性疾病的发生率。耐药微生物的增加已成为一个主要威胁。疫苗的开发仍在进行中，因此需要新的、更安全的治疗替代方案。
对来自南非和纳米比亚的 GBS 分离株进行了苯唑西林、氨苄西林、头孢噻肟、头孢曲松、左氧氟沙星、红霉素、克林霉素、利奈唑胺、万古霉素、四环素和复方磺胺甲噁唑、油橄榄叶提取物和精油的药敏试验。
分离株对苯唑西林、氨苄西林、头孢曲松、左氧氟沙星、利奈唑胺、万古霉素、油橄榄叶提取物和精油均表现出 100%的敏感性。仅 1 株（0.6%）对头孢噻肟耐药，23.4%和 10.4%的分离株分别对克林霉素和红霉素耐药。
GBS 分离株对低最低抑菌浓度的油橄榄叶提取物表现出敏感性。β-内酰胺类药物仍然是治疗 GBS 疾病的首选药物，但油橄榄叶提取物作为一种替代抗菌药物来源具有潜力。
