Chou Yu-Shao, Lin Hsin-Yueh, Weng Yi-Ming, Goh Zhong Ning Leonard, Chien Cheng-Yu, Fan Hsuan-Jui, Li Chih-Huang, Chen Hsien-Yi, Hsieh Ming-Shun, Seak Joanna Chen-Yeen, Seak Chen-Ken, Seak Chen-June
Department of Emergency Medicine, Lin-Kou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Guei-shan Township, Taoyuan, 333, Taiwan, ROC.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Intern Emerg Med. 2020 Jan;15(1):59-66. doi: 10.1007/s11739-019-02037-z. Epub 2019 Jan 31.
Percutaneous coronary interventions (PCIs) within a door-to-balloon timing of 90 min have greatly decreased mortality and morbidity of ST-elevation myocardial infarction (STEMI) patients. Post-PCI, they are routinely transferred into the coronary care unit (CCU) regardless of the severity of their condition, resulting in frequent CCU overcrowding. This study assesses the feasibility of step-down units (SDUs) as an alternative to CCUs in the management of STEMI patients after successful PCI, to alleviate CCU overcrowding. Criteria of assessment include in-hospital complications, length of stay, cost-effectiveness, and patient outcomes up to a year after discharge from hospital. A retrospective case-control study was done using data of 294 adult STEMI patients admitted to the emergency departments of two training and research hospitals and successfully underwent primary PCI from 1 January 2014 to 31 December 2015. Patients were followed up for a year post-discharge. Student t test and χ test were done as univariate analysis to check for statistical significance of p < 0.05. Further regression analysis was done with respect to primary outcomes to adjust for major confounders. Patients managed in the SDU incurred significantly lower inpatient costs (p = 0.0003). No significant differences were found between the CCU and SDU patients in terms of patient characteristics, PCI characteristics, in-hospital complications, length of stay, and patient outcomes up to a year after discharge. The SDU is a viable cost-effective option for managing STEMI patients after successful primary PCI to avoid CCU overcrowding, with non-inferior patient outcomes as compared to the CCU.
在90分钟门球时间内进行的经皮冠状动脉介入治疗(PCI)已大大降低了ST段抬高型心肌梗死(STEMI)患者的死亡率和发病率。PCI术后,无论病情严重程度如何,患者通常都会被转入冠心病监护病房(CCU),这导致CCU经常人满为患。本研究评估了在成功进行PCI后,作为CCU替代方案的降级病房(SDU)用于管理STEMI患者以缓解CCU拥挤状况的可行性。评估标准包括住院并发症、住院时间、成本效益以及出院后长达一年的患者预后。采用2014年1月1日至2015年12月31日期间两所培训和研究医院急诊科收治的294例成功接受直接PCI的成年STEMI患者的数据进行回顾性病例对照研究。患者出院后随访一年。采用学生t检验和χ检验进行单变量分析,以检验p < 0.05的统计学显著性。针对主要结局进行进一步回归分析以调整主要混杂因素。在SDU接受治疗的患者住院费用显著更低(p = 0.0003)。在患者特征、PCI特征、住院并发症、住院时间以及出院后长达一年的患者预后方面,CCU和SDU患者之间未发现显著差异。对于成功进行直接PCI后的STEMI患者,SDU是一种可行的具有成本效益的选择,可避免CCU拥挤,且与CCU相比患者预后不劣。