Laboratory of Biochemistry and Genetics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0830.
J Biol Chem. 2019 Feb 1;294(5):1729-1738. doi: 10.1074/jbc.TM118.004168.
Yeast prions have become important models for the study of the basic mechanisms underlying human amyloid diseases. Yeast prions are pathogenic (unlike the [Het-s] prion of ), and most are amyloid-based with the same in-register parallel β-sheet architecture as most of the disease-causing human amyloids studied. Normal yeast cells eliminate the large majority of prion variants arising, and several anti-prion/anti-amyloid systems that eliminate them have been identified. It is likely that mammalian cells also have anti-amyloid systems, which may be useful in the same way humoral, cellular, and innate immune systems are used to treat or prevent bacterial and viral infections.
酵母朊病毒已成为研究人类淀粉样疾病基本机制的重要模型。酵母朊病毒是致病性的（与 中的 [Het-s] 朊病毒不同），大多数是基于淀粉样蛋白的，与大多数研究过的致病人类淀粉样蛋白具有相同的在位平行β-折叠结构。正常酵母细胞消除了大多数出现的朊病毒变体，已经鉴定出几种消除它们的抗朊病毒/抗淀粉样蛋白系统。哺乳动物细胞也可能有抗淀粉样蛋白系统，这些系统可能以与体液、细胞和先天免疫系统用于治疗或预防细菌和病毒感染相同的方式有用。
