Tan Xin, Shen Fang, Dong Wan-Li, Yang Yi, Chen Gang
Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Med Gas Res. 2019 Jan 9;8(4):176-180. doi: 10.4103/2045-9912.248270. eCollection 2018 Oct-Dec.
Alzheimer's disease is one of the most common neurodegenerative diseases in the elderly. It is often manifested as learning and memory impairment, cognitive function decline, normal social and emotional disorders. However, for this high-risk common disease, there is currently no effective treatment, which has plagued many clinicians. As a new type of medical therapeutic gas, hydrogen has attracted much attention recently. As a recognized reducing gas, hydrogen has shown great anti-oxidative stress and anti-inflammatory effect in many cerebral disease models. It can ameliorate neuronal damage, maintain the number of neurons, prolong the lifespan of neurons, and ultimately inhibit disease progression. Therefore, the role and mechanism of hydrogen in the pathological process of Alzheimer's disease will be discussed in this paper.
阿尔茨海默病是老年人中最常见的神经退行性疾病之一。它常表现为学习和记忆障碍、认知功能下降、正常社交和情感紊乱。然而，对于这种高危常见疾病，目前尚无有效的治疗方法，这一直困扰着许多临床医生。作为一种新型的医用治疗气体，氢气最近备受关注。作为一种公认的还原性气体，氢气在许多脑部疾病模型中已显示出强大的抗氧化应激和抗炎作用。它可以改善神经元损伤，维持神经元数量，延长神经元寿命，并最终抑制疾病进展。因此，本文将探讨氢气在阿尔茨海默病病理过程中的作用及机制。
