Department of Human Development.
Department of Social and Behavioral Sciences, Harvard University.
Cultur Divers Ethnic Minor Psychol. 2019 Jan;25(1):82-90. doi: 10.1037/cdp0000233.
Despite considerable evidence that greater exposure to discrimination over the life course increases risk for systemic inflammation, little is known about the mechanisms responsible for this association. Here we examine the role of global sleep quality as a potential pathway by which self-reported experiences of discrimination contribute to inflammatory dysfunction in a multiethnic sample of middle-aged adults.
Participants were 300 adults (36-85 years; 65% women) from Milwaukee, Wisconsin, a subset of the Midlife in the United States Study 2 (2004-2006). Racial/ethnic representation included African American (77.7%), Hispanic (12.7%), Asian/Pacific Islander (5.6%), and Native American (4.0%). Global sleep quality and perceptions of lifetime and daily discrimination were measured by questionnaire. A composite score of inflammation burden was computed as the sum of five markers including C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, E-selectin, and intracellular adhesion molecule-1 (ICAM-1).
Greater lifetime exposure to discrimination was associated with higher inflammation burden. This relationship remained significant after adjustments for potential confounding factors, including demographics, medication use, health behaviors, psychological distress, and daily discrimination. Mediation analyses suggested that poor global sleep quality was a key mechanism underlying the link between lifetime discrimination and inflammation burden.
These results add to a growing literature on the effects of bias and unfair treatment experienced by people of color and other marginalized groups by demonstrating how such experiences may be particularly consequential for sleep and physiological functioning in midlife. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
尽管有大量证据表明，一生中经历更多的歧视会增加系统性炎症的风险，但人们对导致这种关联的机制知之甚少。在这里，我们研究了整体睡眠质量作为一个潜在途径的作用，即自我报告的歧视经历如何导致中年成年人的炎症功能障碍。
参与者是来自威斯康星州密尔沃基的 300 名成年人（36-85 岁；65%为女性），他们是美国中期生活研究 2 期（2004-2006 年）的一个子样本。种族/民族代表性包括非裔美国人（77.7%）、西班牙裔（12.7%）、亚洲/太平洋岛民（5.6%）和美洲原住民（4.0%）。全球睡眠质量和对终生和日常歧视的看法通过问卷进行测量。炎症负担的综合评分是五个标志物的总和，包括 C 反应蛋白（CRP）、白细胞介素 6（IL-6）、纤维蛋白原、E-选择素和细胞间黏附分子-1（ICAM-1）。
一生中经历更多的歧视与更高的炎症负担有关。在调整了潜在的混杂因素后，包括人口统计学、药物使用、健康行为、心理困扰和日常歧视，这种关系仍然显著。中介分析表明，整体睡眠质量差是导致终生歧视与炎症负担之间联系的关键机制。
这些结果通过证明这些经历如何对中年人的睡眠和生理功能产生特别的影响，为人们对有色人种和其他边缘化群体所经历的偏见和不公平待遇的研究增添了新的内容。（PsycINFO 数据库记录（c）2019 APA，保留所有权利）。
