Lu Chengzhe, Yu Shasha, Song Hui, Zhao Yun, Xie Shiyong, Tang Xin, Yuan Xiaoyong
Tianjin Eye Hospital, No.4 Gansu Road, Heping District, Tianjin, 300020, China.
Tianjin Eye Institute, Tianjin, China.
BMC Ophthalmol. 2019 Feb 4;19(1):40. doi: 10.1186/s12886-019-1051-z.
To compare the influence of posterior capsule opacification (PCO) morphology and severity on intraocular stray light and visual function with different levels of contrast.
Forty-five patients diagnosed with PCO were included in this prospective consecutive case series. The Optical Quality Analysis System II (OQAS II) was adopted to assess the objective visual function including objective scatter index (OSI) and optical quality analysis system values (OVs) with 100, 20, and 9% contrast. RTVue-100 OCT was used to evaluate the PCO morphology and severity. Comparisons among visual function, morphology, and severity between pear type and fibrosis PCO were performed. The correlations among the PCO morphology, severity, OSI, and OVs were also determined.
There was a significant correlation between increased OSI and decreased visual acuity in PCO patients before laser capsulotomy. The changes of OSI were also correlated with the PCO area for the 3 mm IOL optic region (r = 0.43, p = 0.02). The OSI was significantly higher in pear type PCO when compared with fibrosis PCO (Z = - 4.06, p ≤ 0.001). In addition, the increased OSI in pear type PCO was significantly correlated with the 100% OVs and the 20% OVs but not with the 9% OVs. In fibrosis PCO, OSI was only correlated with the 100% OVs and the 20% OVs pre-YAG.
OSI and OVs could objectively indicate the visual function impairment in PCO patients. Effects of PCO on light scattering and on objective visual function might be explained by the variations of morphology and severity.
比较不同对比度水平下后囊膜混浊（PCO）的形态和严重程度对眼内杂散光及视觉功能的影响。
本前瞻性连续病例系列纳入了45例诊断为PCO的患者。采用光学质量分析系统II（OQAS II）评估客观视觉功能，包括在对比度为100%、20%和9%时的客观散射指数（OSI）和光学质量分析系统值（OVs）。使用RTVue - 100 OCT评估PCO的形态和严重程度。对梨形和纤维化PCO的视觉功能、形态和严重程度进行比较。还确定了PCO形态、严重程度、OSI和OVs之间的相关性。
在激光晶状体后囊切开术前，PCO患者中OSI升高与视力下降之间存在显著相关性。OSI的变化也与3毫米人工晶状体光学区的PCO面积相关（r = 0.43，p = 0.02）。与纤维化PCO相比，梨形PCO的OSI显著更高（Z = - 4.06，p≤0.001）。此外，梨形PCO中升高的OSI与100% OVs和20% OVs显著相关，但与9% OVs无关。在纤维化PCO中，OSI仅与YAG激光治疗前的100% OVs和20% OVs相关。
OSI和OVs可以客观地表明PCO患者的视觉功能损害。PCO对光散射和客观视觉功能的影响可能由形态和严重程度的变化来解释。
