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通过序列捕获和关联遗传学从野生作物近缘种中克隆抗性基因。

Resistance gene cloning from a wild crop relative by sequence capture and association genetics.

机构信息

John Innes Centre, Norwich Research Park, Norwich, UK.

Commonwealth Scientific and Industrial Research Organization Agriculture and Food, Canberra, Australian Capital Territory, Australia.

出版信息

Nat Biotechnol. 2019 Feb;37(2):139-143. doi: 10.1038/s41587-018-0007-9. Epub 2019 Feb 4.

DOI:10.1038/s41587-018-0007-9
PMID:30718880
Abstract

Disease resistance (R) genes from wild relatives could be used to engineer broad-spectrum resistance in domesticated crops. We combined association genetics with R gene enrichment sequencing (AgRenSeq) to exploit pan-genome variation in wild diploid wheat and rapidly clone four stem rust resistance genes. AgRenSeq enables R gene cloning in any crop that has a diverse germplasm panel.

摘要

来自野生近缘种的抗病（R）基因可用于培育驯化作物的广谱抗性。我们将关联遗传学与 R 基因富集测序（AgRenSeq）相结合，利用野生二倍体小麦的泛基因组变异，快速克隆了四个茎锈病抗性基因。AgRenSeq 使任何具有多样化种质资源的作物都能够进行 R 基因克隆。

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