Opadeyi Abimbola O, Fourrier-Réglat Annie, Isah Ambrose O
Department of Medicine, University of Benin Teaching Hospital, Benin-City, Nigeria.
Pharmacoepidemiology, Université de Bordeaux, Bordeaux, France Bordeaux PharmacoEpi, INSERM CIC1401, Bordeaux, France.
Ther Adv Drug Saf. 2019 Jan 25;10:2042098618816279. doi: 10.1177/2042098618816279. eCollection 2019.
Our aim in this study was to evaluate the effect of a combined educational intervention and year-long monthly text message reinforcements the Short Messaging System (SMS) on the knowledge, attitude and practice (KAP) of healthcare professionals (HCPs) towards pharmacovigilance.
Six randomly selected teaching hospitals in the South-South zone of Nigeria were randomized in 1:1 ratio into intervention and control groups. The educational intervention consisted of delivering a seminar followed by sending monthly texts message reinforcements SMS over 12 months. Then a semi-structured questionnaire regarding the KAP of pharmacovigilance was completed by HCPs working in the hospitals after the intervention. Data was analysed descriptively and inferentially.
A total of 931 HCPs participated in the post intervention study (596 in the intervention and 335 in the control). The M:F ratio was 1:1.5. According to the KAP questionnaire, a significant difference was observed between the intervention and control groups, regarding knowledge of the types of adverse drug reactions (ADRs). ADR resulting from pharmacological action of the drug (85.6% 77%, = 0.001), the fact that ADRs can persist for a long time; (60.1% 53.4%, = 0.024) and a higher awareness of the ADR reporting form (48.7% 18.8%, < 0.001). Most respondents in the intervention group (68.5% 60.6%, = 0.001) believed they should report ADRs even if they were unsure an ADR has occurred, a greater proportion of HCPs from the intervention group had significantly observed an ADR (82% 73.4%, = 0.001). Furthermore, of the 188 who had ever reported an ADR, 41% from the intervention group used the national ADR reporting form compared with 19.8% from the controls ( < 0.001).
This educational intervention and the use of SMS as a reinforcement tool appeared to have positively impacted on the knowledge and practice of pharmacovigilance in South-South Nigeria with a less-than-impressive change in attitude. Continuous medical education may be required to effect long-lasting changes.
本研究的目的是评估联合教育干预以及为期一年每月通过短信强化（短消息服务，SMS）对医疗保健专业人员（HCPs）药物警戒知识、态度和实践（KAP）的影响。
在尼日利亚南南地区随机选择6家教学医院，按1:1比例随机分为干预组和对照组。教育干预包括举办一次研讨会，随后在12个月内每月发送短信强化（SMS）。干预后，由在医院工作的HCPs完成一份关于药物警戒KAP的半结构化问卷。对数据进行描述性和推断性分析。
共有931名HCPs参与了干预后研究（干预组596名，对照组335名）。男女比例为1:1.5。根据KAP问卷，在药物不良反应（ADR）类型的知识方面，干预组和对照组之间存在显著差异。由药物药理作用导致的ADR（85.6%对77%，P = 0.001），ADR可能持续很长时间这一事实（60.1%对53.4%，P = 0.024），以及对ADR报告表的更高知晓率（48.7%对18.8%，P < 0.001）。干预组中的大多数受访者（68.5%对60.6%，P = 0.001）认为即使不确定是否发生了ADR也应该报告，干预组中有更大比例的HCPs显著观察到了ADR（82%对73.4%，P = 0.001）。此外，在曾经报告过ADR的188人中，干预组有41%使用了国家ADR报告表，而对照组为19.8%（P < 0.001）。
这种教育干预以及将SMS用作强化工具似乎对尼日利亚南南地区的药物警戒知识和实践产生了积极影响，但态度变化不太明显。可能需要持续医学教育来实现持久改变。
