Department of Pathology, Department of Medicine and Ronald O. Perelman Department of Dermatology, NYU School of Medicine, New York, NY, USA.
Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Int Immunol. 2019 Jul 13;31(7):415-422. doi: 10.1093/intimm/dxy088.
The skin epithelium covers our body and serves as a vital interface with the external environment. Here, we review the context-specific interactions between immune cells and the epithelium that underlie barrier fitness and function. We highlight the mechanisms by which these two systems engage each other and how immune-epithelial interactions are tuned by microbial and inflammatory stimuli. Epithelial homeostasis relies on a delicate balance of immune surveillance and tolerance, breakdown of which results in disease. In addition to their canonical immune functions, resident and recruited immune cells also supply the epithelium with instructive signals to promote repair. Decoding the dialogue between immunity and the epithelium therefore has great potential for boosting barrier function or mitigating inflammatory epithelial diseases.
皮肤上皮组织覆盖着我们的身体，是与外部环境进行重要交互的界面。在这里，我们回顾了免疫细胞与上皮组织之间的特定环境相互作用，这些相互作用是维持屏障健康和功能的基础。我们强调了这两个系统相互作用的机制，以及免疫-上皮相互作用如何受到微生物和炎症刺激的调节。上皮组织的稳态依赖于免疫监视和耐受之间的微妙平衡，这种平衡的打破会导致疾病。除了其经典的免疫功能外，固有免疫细胞和募集的免疫细胞也为上皮组织提供了指导信号，以促进修复。因此，解码免疫和上皮组织之间的对话具有增强屏障功能或减轻炎症性上皮疾病的巨大潜力。
