Laboratory of Reproductive Toxicology, Department of Pharmacy, State University of Centro-Oeste, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil.
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524, 05508-000 São Paulo, Brazil.
Food Chem. 2019 Jun 15;283:422-430. doi: 10.1016/j.foodchem.2019.01.054. Epub 2019 Jan 17.
The endocrine system is highly sensitive to endocrine-disrupting chemicals (EDC) which interfere with metabolism, growth and reproduction throughout different periods of life, especially in the embryonic and pubertal stages, in which gene reprogramming may be associated with impaired development and control of tissues/organs even in adulthood. Acrylamide is considered a potential EDC and its main source comes from fried, baked and roasted foods that are widely consumed by children, teenagers and adults around the world. This review aimed to present some aspects regarding the acrylamide formation, its toxicokinetics, the occurrence of acrylamide in foods, the recent findings about its effects on different systems and the consequences for the human healthy. The challenges to characterize the molecular mechanisms triggered by acrylamide and to establish safe levels of consumption and/or exposure are also discussed in the present review.
内分泌系统对外源干扰内分泌化学物质（EDC）非常敏感，这些化学物质会干扰代谢、生长和生殖在生命的不同阶段，尤其是在胚胎和青春期，在这个阶段，基因重编程可能与组织/器官发育受损和控制有关，甚至在成年期也是如此。丙烯酰胺被认为是一种潜在的 EDC，其主要来源来自油炸、烘焙和烤制食品，这些食品在世界各地的儿童、青少年和成年人中广泛食用。本综述旨在介绍一些关于丙烯酰胺形成、其毒代动力学、食品中丙烯酰胺的发生、其对不同系统影响的最新发现以及对人类健康的影响的方面。本综述还讨论了丙烯酰胺引发的分子机制的特征描述以及确定安全消费和/或暴露水平的挑战。
