宿主细胞骨架在黄病毒感染中的作用。
The Role of Host Cytoskeleton in Flavivirus Infection.
机构信息
CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Virol Sin. 2019 Feb;34(1):30-41. doi: 10.1007/s12250-019-00086-4. Epub 2019 Feb 6.
Abstract
The family of flaviviruses is one of the most medically important groups of emerging arthropod-borne viruses. Host cell cytoskeletons have been reported to have close contact with flaviviruses during virus entry, intracellular transport, replication, and egress process, although many detailed mechanisms are still unclear. This article provides a brief overview of the function of the most prominent flaviviruses-induced or -hijacked cytoskeletal structures including actin, microtubules and intermediate filaments, mainly focus on infection by dengue virus, Zika virus and West Nile virus. We suggest that virus interaction with host cytoskeleton to be an interesting area of future research.
摘要
黄病毒家族是最重要的新兴节肢动物传播病毒群之一。据报道，在病毒进入、细胞内运输、复制和释放过程中，宿主细胞细胞骨架与黄病毒密切接触，尽管许多详细机制仍不清楚。本文简要概述了最主要的黄病毒诱导或劫持的细胞骨架结构（包括肌动蛋白、微管和中间丝）的功能，主要集中在登革热病毒、寨卡病毒和西尼罗河病毒感染方面。我们认为病毒与宿主细胞骨架的相互作用是未来研究的一个有趣领域。
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