Jacobson J A, Call N B, Kasworm E M, Dirks M S, Turner R B
Division of Infectious Diseases, LDS Hospital, Salt Lake City, Utah.
Antimicrob Agents Chemother. 1988 Dec;32(12):1820-4. doi: 10.1128/AAC.32.12.1820.
Bacterial conjunctivitis appears to resolve more rapidly when treated with appropriate topical antimicrobial agents. In this multicenter, randomized, double-blind study of efficacy and safety, patients with presumed bacterial external eye infections were assigned to topical therapy with 0.3% norfloxacin or 0.3% tobramycin. A total of 120 patients were enrolled. Of the total, 65 had documented bacterial infections and were evaluable; 59 of these patients had bacterial conjunctivitis. All of the patients with documented infections were cured or improved regardless of the drug treatment regimen or in vitro susceptibility testing results. The most common bacteria isolated were Haemophilus influenzae, Streptococcus pneumoniae, alpha-hemolytic streptococci, Staphylococcus aureus, and Staphylococcus sp. No patients had serious adverse reactions attributed to their therapy. Norfloxacin ophthalmic solution seems to be a safe, effective, and appropriate agent for the treatment of bacterial external eye infections.
使用适当的局部抗菌药物治疗时，细菌性结膜炎似乎能更快痊愈。在这项关于疗效和安全性的多中心、随机、双盲研究中，疑似细菌性外眼感染患者被分配接受0.3%诺氟沙星或0.3%妥布霉素的局部治疗。总共招募了120名患者。其中，65例有记录的细菌感染且可进行评估；这些患者中有59例患有细菌性结膜炎。所有有记录感染的患者无论药物治疗方案或体外药敏试验结果如何均已治愈或病情改善。分离出的最常见细菌为流感嗜血杆菌、肺炎链球菌、α溶血性链球菌、金黄色葡萄球菌和葡萄球菌属。没有患者因治疗出现严重不良反应。诺氟沙星滴眼液似乎是治疗细菌性外眼感染的一种安全、有效且合适的药物。
